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The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.
Sakurai T. Sakurai T. Nat Rev Neurosci. 2007 Mar;8(3):171-81. doi: 10.1038/nrn2092. Epub 2007 Feb 14. Nat Rev Neurosci. 2007. PMID: 17299454 Review.
Orexin (hypocretin) neurons contain dynorphin.
Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE. Chou TC, et al. J Neurosci. 2001 Oct 1;21(19):RC168. doi: 10.1523/JNEUROSCI.21-19-j0003.2001. J Neurosci. 2001. PMID: 11567079 Free PMC article.
Plasma orexin-A is lower in patients with narcolepsy.
Higuchi S, Usui A, Murasaki M, Matsushita S, Nishioka N, Yoshino A, Matsui T, Muraoka H, Ishizuka Y, Kanba S, Sakurai T. Higuchi S, et al. Neurosci Lett. 2002 Jan 25;318(2):61-4. doi: 10.1016/s0304-3940(01)02476-4. Neurosci Lett. 2002. PMID: 11796186
Orexins activate histaminergic neurons via the orexin 2 receptor.
Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T. Yamanaka A, et al. Biochem Biophys Res Commun. 2002 Feb 1;290(4):1237-45. doi: 10.1006/bbrc.2001.6318. Biochem Biophys Res Commun. 2002. PMID: 11811995
Involvement of the serotonergic system in orexin-induced behavioral alterations in rats.
Matsuzaki I, Sakurai T, Kunii K, Nakamura T, Yanagisawa M, Goto K. Matsuzaki I, et al. Regul Pept. 2002 Mar 15;104(1-3):119-23. doi: 10.1016/s0167-0115(01)00355-x. Regul Pept. 2002. PMID: 11830286
Effects of orexin on cultured porcine adrenal medullary and cortex cells.
Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Goto K, Nakai T. Nanmoku T, et al. Regul Pept. 2002 Mar 15;104(1-3):125-30. doi: 10.1016/s0167-0115(01)00356-1. Regul Pept. 2002. PMID: 11830287
The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus.
Moriguchi T, Sakurai T, Takahashi S, Goto K, Yamamoto M. Moriguchi T, et al. J Biol Chem. 2002 May 10;277(19):16985-92. doi: 10.1074/jbc.M107962200. Epub 2002 Feb 19. J Biol Chem. 2002. PMID: 11854267
Roles of orexins in regulation of feeding and wakefulness.
Sakurai T. Sakurai T. Neuroreport. 2002 Jun 12;13(8):987-95. doi: 10.1097/00001756-200206120-00001. Neuroreport. 2002. PMID: 12060794 Review.
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