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Interleukin-1 beta induced activation of NF-kappa B in insulin producing RINm5F cells is prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone.
Saldeen J, Welsh N. Saldeen J, et al. Biochem Biophys Res Commun. 1994 Aug 30;203(1):149-55. doi: 10.1006/bbrc.1994.2161. Biochem Biophys Res Commun. 1994. PMID: 8074648
The role of the adapter protein SHB in embryonic stem cell differentiation into the pancreatic beta-cell and endothelial lineages.
Saldeen J, Agren N, Akerblom B, Lu L, Adem B, Sedek L, Kriz V. Saldeen J, et al. Methods Mol Biol. 2006;330:353-72. doi: 10.1385/1-59745-036-7:353. Methods Mol Biol. 2006. PMID: 16846036
SHB and angiogenic factors promote ES cell differentiation to insulin-producing cells.
Saldeen J, Kriz V, Agren N, Welsh M. Saldeen J, et al. Biochem Biophys Res Commun. 2006 Jun 2;344(2):517-24. doi: 10.1016/j.bbrc.2006.03.129. Epub 2006 Apr 19. Biochem Biophys Res Commun. 2006. PMID: 16630561
p38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells.
Saldeen J, Welsh N. Saldeen J, et al. Eur Cytokine Netw. 2004 Jan-Mar;15(1):47-52. Eur Cytokine Netw. 2004. PMID: 15217752 Free article.
Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Deltapsi(m)) in pancreatic RINm5F cells: prevention by Bcl-2.
Barbu A, Welsh N, Saldeen J. Barbu A, et al. Among authors: saldeen j. Mol Cell Endocrinol. 2002 Apr 25;190(1-2):75-82. doi: 10.1016/s0303-7207(02)00009-6. Mol Cell Endocrinol. 2002. PMID: 11997180
Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis.
Saldeen J, Tillmar L, Karlsson E, Welsh N. Saldeen J, et al. Mol Cell Biochem. 2003 Jan;243(1-2):113-22. doi: 10.1023/a:1021651811345. Mol Cell Biochem. 2003. PMID: 12619896
Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis.
Saldeen J, Lee JC, Welsh N. Saldeen J, et al. Biochem Pharmacol. 2001 Jun 15;61(12):1561-9. doi: 10.1016/s0006-2952(01)00605-0. Biochem Pharmacol. 2001. PMID: 11377386
The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha-mediated potentiation of IL-1beta-induced NF-kappaB activation in the insulin-producing cell line Rinm5F.
Saldeen J, Jaffrézou JP, Welsh N. Saldeen J, et al. Autoimmunity. 2000 Dec;32(4):241-54. doi: 10.3109/08916930008994098. Autoimmunity. 2000. PMID: 11191283
Novel experimental strategies to prevent the development of type 1 diabetes mellitus.
Sandler S, Andersson AK, Barbu A, Hellerström C, Holstad M, Karlsson E, Sandberg JO, Strandell E, Saldeen J, Sternesjö J, Tillmar L, Eizirik DL, Flodström M, Welsh N. Sandler S, et al. Among authors: saldeen j. Ups J Med Sci. 2000;105(2):17-34. doi: 10.1517/03009734000000053. Ups J Med Sci. 2000. PMID: 11095103 Review.
Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells.
Saldeen J. Saldeen J. Endocrinology. 2000 Jun;141(6):2003-10. doi: 10.1210/endo.141.6.7523. Endocrinology. 2000. PMID: 10830283
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