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Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells.
Vieira E, Salehi A, Gylfe E. Vieira E, et al. Diabetologia. 2007 Feb;50(2):370-9. doi: 10.1007/s00125-006-0511-1. Epub 2006 Nov 29. Diabetologia. 2007. PMID: 17136393
Although somatostatin secretion data seemed consistent with a role of this hormone in glucose-inhibited glucagon release, a somatostatin receptor type 2 antagonist stimulated glucagon release without diminishing the inhibitory effect of glucose. ...We instead propos …
Although somatostatin secretion data seemed consistent with a role of this hormone in glucose-inhibited glucagon release, a so …
Pancreatic β-cell dysfunction, expression of iNOS and the effect of phosphodiesterase inhibitors in human pancreatic islets of type 2 diabetes.
Muhammed SJ, Lundquist I, Salehi A. Muhammed SJ, et al. Diabetes Obes Metab. 2012 Nov;14(11):1010-9. doi: 10.1111/j.1463-1326.2012.01632.x. Epub 2012 Jul 4. Diabetes Obes Metab. 2012. PMID: 22687049
CONCLUSION: Our results suggest that in islets from type 2 diabetes, stimulatory effects in certain cAMP-compartments induced by PDE inhibitors might play a central role in the suppression of iNOS, resulting in increased β-cell viability and improved secretory response to …
CONCLUSION: Our results suggest that in islets from type 2 diabetes, stimulatory effects in certain cAMP-compartments induced by PDE inhibit …
Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.
Collins SC, Salehi A, Eliasson L, Olofsson CS, Rorsman P. Collins SC, et al. Diabetologia. 2008 Sep;51(9):1689-93. doi: 10.1007/s00125-008-1082-0. Epub 2008 Jul 12. Diabetologia. 2008. PMID: 18622593 Free PMC article.
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Amisten S, Meidute-Abaraviciene S, Tan C, Olde B, Lundquist I, Salehi A, Erlinge D. Amisten S, et al. Diabetologia. 2010 Sep;53(9):1927-34. doi: 10.1007/s00125-010-1807-8. Epub 2010 Jun 6. Diabetologia. 2010. PMID: 20526761
Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.
Gromada J, Høy M, Buschard K, Salehi A, Rorsman P. Gromada J, et al. J Physiol. 2001 Sep 1;535(Pt 2):519-32. doi: 10.1111/j.1469-7793.2001.00519.x. J Physiol. 2001. PMID: 11533141 Free PMC article.
The inhibitory effect of somatostatin on exocytosis was mediated by activation of the serine/threonine protein phosphatase calcineurin and was prevented by pretreatment with cyclosporin A and deltamethrin or intracellularly applied calcineurin autoinhibitory peptide. ...We …
The inhibitory effect of somatostatin on exocytosis was mediated by activation of the serine/threonine protein phosphatase calcineurin and w …
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
Taneera J, Jin Z, Jin Y, Muhammed SJ, Zhang E, Lang S, Salehi A, Korsgren O, Renström E, Groop L, Birnir B. Taneera J, et al. Diabetologia. 2012 Jul;55(7):1985-94. doi: 10.1007/s00125-012-2548-7. Epub 2012 Apr 27. Diabetologia. 2012. PMID: 22538358 Free PMC article.
The currents were enhanced by pentobarbital and inhibited by the GABA(A) receptor antagonist, SR95531. The effects of SR95531 on hormone release revealed that activation of GABA(A) channels (GABA(A) receptors) decreased both insulin and glucagon secretion. .. …
The currents were enhanced by pentobarbital and inhibited by the GABA(A) receptor antagonist, SR95531. The effects of SR95531 on horm …
Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse.
Meidute-Abaraviciene S, Mosen H, Lundquist I, Salehi A. Meidute-Abaraviciene S, et al. Acta Physiol (Oxf). 2009 Mar;195(3):375-83. doi: 10.1111/j.1748-1716.2008.01896.x. Epub 2008 Sep 1. Acta Physiol (Oxf). 2009. PMID: 18764864
Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities.
Abaraviciene SM, Lundquist I, Salehi A. Abaraviciene SM, et al. Cell Mol Life Sci. 2008 Jul;65(14):2256-65. doi: 10.1007/s00018-008-8100-8. Cell Mol Life Sci. 2008. PMID: 18560759
Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion.
Salehi A, Flodgren E, Nilsson NE, Jimenez-Feltstrom J, Miyazaki J, Owman C, Olde B. Salehi A, et al. Cell Tissue Res. 2005 Nov;322(2):207-15. doi: 10.1007/s00441-005-0017-z. Epub 2005 Nov 3. Cell Tissue Res. 2005. PMID: 16044321
Mouse islets were subjected to antisense intervention by treatment with a FFA(1)R/GPR40-specific morpholino oligonucleotide for 48 h. ...
Mouse islets were subjected to antisense intervention by treatment with a FFA(1)R/GPR40-specific morpholino oligonucleotide for 48 h. …
Signal transduction in islet hormone release: interaction of nitric oxide with basal and nutrient-induced hormone responses.
Salehi A, Parandeh F, Lundquist I. Salehi A, et al. Cell Signal. 1998 Oct;10(9):645-51. doi: 10.1016/s0898-6568(98)00005-9. Cell Signal. 1998. PMID: 9794246
In a medium devoid of any nutrient, the NO synthase (NOS)-inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) induced an increase in basal insulin release but a decrease in glucagon release. ...Our data suggest that islet hormone secretion in a medium devoi …
In a medium devoid of any nutrient, the NO synthase (NOS)-inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) induced an increase i …
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