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Role of morphine glucuronide metabolites in morphine dependence in the rat.
Salem A, Hope W. Salem A, et al. Pharmacol Biochem Behav. 1997 Aug;57(4):801-7. doi: 10.1016/s0091-3057(96)00471-6. Pharmacol Biochem Behav. 1997. PMID: 9259009
Potentiation of 3,4-methylenedioxymethamphetamine-induced 5-HT release in the rat substantia nigra by clorgyline, a monoamine oxidase A inhibitor.
Hewton R, Salem A, Irvine RJ. Hewton R, et al. Clin Exp Pharmacol Physiol. 2007 Oct;34(10):1051-7. doi: 10.1111/j.1440-1681.2007.04734.x. Clin Exp Pharmacol Physiol. 2007. PMID: 17714093
The present study compared the abilities of PMA and MDMA to increase extracellular 5-HT concentrations in animals with functional MAO-A and when MAO-A activity was inhibited by clorgyline. 3. ...The results of the present study suggest that PMA and MDMA are similar …
The present study compared the abilities of PMA and MDMA to increase extracellular 5-HT concentrations in animals with functional MAO-A
Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine.
Callaghan PD, Farrand K, Salem A, Hughes P, Daws LC, Irvine RJ. Callaghan PD, et al. Eur J Pharmacol. 2006 Sep 28;546(1-3):74-81. doi: 10.1016/j.ejphar.2006.07.011. Epub 2006 Jul 25. Eur J Pharmacol. 2006. PMID: 16925993
When rats were housed at a higher ambient temperature (28 degrees C vs. 22 degrees C) for 6 h after dosing, no additive effect was seen for either drug. A more intensive dosing regimen (10 or 20 mg/kg twice daily for 4 days) was used to examine PMA/MDMA effects on c …
When rats were housed at a higher ambient temperature (28 degrees C vs. 22 degrees C) for 6 h after dosing, no additive effect was se …
Effects of 3,4-methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral thermoregulation.
Jaehne EJ, Salem A, Irvine RJ. Jaehne EJ, et al. Pharmacol Biochem Behav. 2005 Jul;81(3):485-96. doi: 10.1016/j.pbb.2005.04.005. Pharmacol Biochem Behav. 2005. PMID: 15904952
Rats were administered an amphetamine or saline and confined to an ambient temperature of 21, 30 or 15 degrees C for 30 min, before being able to choose their preferred temperature (T(P)) on a thermally graded runway (11-41 degrees C). ...In contrast, at 15 degrees C MDMA …
Rats were administered an amphetamine or saline and confined to an ambient temperature of 21, 30 or 15 degrees C for 30 min, before being ab …
Absorption of morphine from a slow-release emulsion used to induce morphine dependence in rats.
Salem A, Hope W. Salem A, et al. J Pharmacol Toxicol Methods. 1998 Oct;40(3):159-64. doi: 10.1016/s1056-8719(98)00050-1. J Pharmacol Toxicol Methods. 1998. PMID: 10334632
Both morphine base- and hydrochloride-containing emulsions induced a high degree of physical dependence in animals treated over 48 h. ...These results suggest that morphine base containing emulsions provide a more sustained exposure to the opioid....
Both morphine base- and hydrochloride-containing emulsions induced a high degree of physical dependence in animals treated over 48 h. …
A study on seasonal variation in the development of morphine dependence in rats.
Salem A, Hope W. Salem A, et al. J Pharmacol Toxicol Methods. 1998 Oct;40(3):151-7. doi: 10.1016/s1056-8719(98)00047-1. J Pharmacol Toxicol Methods. 1998. PMID: 10334631
The experiments were carried out at monthly intervals over a 2-year period using rats treated with a morphine-containing slow-release emulsion. The results obtained from these experiments were equivocal, neither providing support for seasonal variance in the express …
The experiments were carried out at monthly intervals over a 2-year period using rats treated with a morphine-containing slow- …
Role of endogenous adenosine in the expression of opiate withdrawal in rats.
Salem A, Hope W. Salem A, et al. Eur J Pharmacol. 1999 Mar 12;369(1):39-42. doi: 10.1016/s0014-2999(99)00046-1. Eur J Pharmacol. 1999. PMID: 10204679
Effect of adenosine receptor agonists and antagonists on the expression of opiate withdrawal in rats.
Salem A, Hope W. Salem A, et al. Pharmacol Biochem Behav. 1997 Aug;57(4):671-9. doi: 10.1016/s0091-3057(96)00393-0. Pharmacol Biochem Behav. 1997. PMID: 9258993
Both CPA and CGS 21680, caused a significant reduction in the incidence of body shakes, teeth chatter and paw shakes and decreased the amount of faecal matter produced. ...These data suggest that there is a role for endogenous adenosine in the modulation of the opia …
Both CPA and CGS 21680, caused a significant reduction in the incidence of body shakes, teeth chatter and paw shakes and decreased th …
Analysis of buprenorphine in rat plasma using a solid-phase extraction technique and high-performance liquid chromatography with electrochemical detection.
Salem A, Pierce TL, Hope W. Salem A, et al. J Pharmacol Toxicol Methods. 1997 Mar;37(2):75-81. doi: 10.1016/s1056-8719(97)00001-4. J Pharmacol Toxicol Methods. 1997. PMID: 9174982
A solid-phase extraction method and sensitive reversed phase high-performance liquid chromatography analysis with electrochemical detection of buprenorphine and its metabolite, norbuprenorphine, in rat plasma is described. Adequate separation of the compounds of interest w
A solid-phase extraction method and sensitive reversed phase high-performance liquid chromatography analysis with electrochemical det
Model of methadone-induced hyperalgesia in rats and effect of memantine.
Hay JL, Kaboutari J, White JM, Salem A, Irvine R. Hay JL, et al. Eur J Pharmacol. 2010 Jan 25;626(2-3):229-33. doi: 10.1016/j.ejphar.2009.09.056. Epub 2009 Oct 8. Eur J Pharmacol. 2010. PMID: 19818750
A separate cohort of rats received either methadone 1mg/kg/day (n=8) or methadone 1mg/kg/day with 20mg/kg/day memantine (n=8). ...Methadone only treated rats had a mean paw withdrawal latency significantly lower than the corresponding values for saline on days 8, 9,
A separate cohort of rats received either methadone 1mg/kg/day (n=8) or methadone 1mg/kg/day with 20mg/kg/day memantine (n=8). ...Met
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