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In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.
Cummins CL, Salphati L, Reid MJ, Benet LZ. Cummins CL, et al. Among authors: salphati l. J Pharmacol Exp Ther. 2003 Apr;305(1):306-14. doi: 10.1124/jpet.102.044719. J Pharmacol Exp Ther. 2003. PMID: 12649383
Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.
Salphati L, Benet LZ. Salphati L, et al. Biochem Pharmacol. 1998 Feb 15;55(4):387-95. doi: 10.1016/s0006-2952(97)00436-x. Biochem Pharmacol. 1998. PMID: 9514072
Effects of ketoconazole on digoxin absorption and disposition in rat.
Salphati L, Benet LZ. Salphati L, et al. Pharmacology. 1998 Jun;56(6):308-13. doi: 10.1159/000028214. Pharmacology. 1998. PMID: 9654217
When given intravenously, digoxin AUC increased from 93 +/- 22 to 486 +/- 26 microg x h/l with ketoconazole administration. Similarly, ketoconazole raised the AUC of orally administered digoxin from 63 +/- 17 to 411 +/- 50 microg x h/l. ...
When given intravenously, digoxin AUC increased from 93 +/- 22 to 486 +/- 26 microg x h/l with ketoconazole administration. Similarly …
Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.
Salphati L, Benet LZ. Salphati L, et al. Xenobiotica. 1999 Feb;29(2):171-85. doi: 10.1080/004982599238722. Xenobiotica. 1999. PMID: 10199593
Evaluation of a single-pass intestinal-perfusion method in rat for the prediction of absorption in man.
Salphati L, Childers K, Pan L, Tsutsui K, Takahashi L. Salphati L, et al. J Pharm Pharmacol. 2001 Jul;53(7):1007-13. doi: 10.1211/0022357011776252. J Pharm Pharmacol. 2001. PMID: 11480535
Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.
Salphati L, Lee LB, Pang J, Plise EG, Zhang X. Salphati L, et al. Drug Metab Dispos. 2010 Sep;38(9):1422-6. doi: 10.1124/dmd.110.034256. Epub 2010 Jun 3. Drug Metab Dispos. 2010. PMID: 20522663
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Dallas S, Salphati L, Gomez-Zepeda D, Wanek T, Chen L, Chu X, Kunta J, Mezler M, Menet MC, Chasseigneaux S, Declèves X, Langer O, Pierre E, DiLoreto K, Hoft C, Laplanche L, Pang J, Pereira T, Andonian C, Simic D, Rode A, Yabut J, Zhang X, Scheer N. Dallas S, et al. Among authors: salphati l. Mol Pharmacol. 2016 May;89(5):492-504. doi: 10.1124/mol.115.102079. Epub 2016 Feb 18. Mol Pharmacol. 2016. PMID: 26893303
Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD. Prasad B, et al. Among authors: salphati l. Clin Pharmacol Ther. 2016 Oct;100(4):362-70. doi: 10.1002/cpt.409. Epub 2016 Aug 13. Clin Pharmacol Ther. 2016. PMID: 27301780 Free PMC article.
Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations.
Ronaldson PT, Bauer B, El-Kattan AF, Shen H, Salphati L, Louie SW. Ronaldson PT, et al. Among authors: salphati l. Clin Pharmacol Ther. 2016 Nov;100(5):419-422. doi: 10.1002/cpt.439. Epub 2016 Sep 13. Clin Pharmacol Ther. 2016. PMID: 27500791 Free PMC article.
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.
Cepa S, Potter D, Wong L, Schutt L, Tarrant J, Pang J, Zhang X, Andaya R, Salphati L, Ran Y, An L, Morgan R, Maher J. Cepa S, et al. Among authors: salphati l. Toxicol Appl Pharmacol. 2018 Jan 1;338:204-213. doi: 10.1016/j.taap.2017.11.007. Epub 2017 Nov 13. Toxicol Appl Pharmacol. 2018. PMID: 29146462
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