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Syntheses of isotope-labeled SGLT2 inhibitor canagliflozin (JNJ-28431754).
Lin R, Hoerr DC, Weaner LE, Salter R. Lin R, et al. J Labelled Comp Radiopharm. 2017 Nov;60(13):616-623. doi: 10.1002/jlcr.3542. Epub 2017 Sep 18. J Labelled Comp Radiopharm. 2017. PMID: 28833358
A short synthesis of d-[1-(14) C]-serine of high enantiomeric purity.
Song F, Salter R, Weaner LE. Song F, et al. J Labelled Comp Radiopharm. 2015 Apr;58(4):173-6. doi: 10.1002/jlcr.3272. Epub 2015 Feb 27. J Labelled Comp Radiopharm. 2015. PMID: 25728900
Starting from [(14) C]-KCN and 2-(benzyloxy)acetaldehyde, Strecker reaction using (R)-1-phenylethylamine as the chiral auxiliary gave two diastereomeric aminonitriles 1 and 2 in the ratio of 4:3, which were conveniently separated and purified chromatographically. ...
Starting from [(14) C]-KCN and 2-(benzyloxy)acetaldehyde, Strecker reaction using (R)-1-phenylethylamine as the chiral auxiliary gave …
Standard-Free Bioanalytical Approach for Absolute Quantitation of Drug Metabolites Utilizing Biosynthesis of Reciprocal Radio and Stable Isotopologues and Its Application.
Gong Y, Chen J, Shi Y, Lim HK, Weng N, Salter R. Gong Y, et al. Anal Chem. 2017 Aug 15;89(16):8399-8404. doi: 10.1021/acs.analchem.7b01830. Epub 2017 Jul 25. Anal Chem. 2017. PMID: 28696683
Synthesis of carbon-14 labeled ketamine and norketamine.
Chen L, Gong Y, Salter R. Chen L, et al. J Labelled Comp Radiopharm. 2018 Sep;61(11):864-868. doi: 10.1002/jlcr.3669. Epub 2018 Jul 29. J Labelled Comp Radiopharm. 2018. PMID: 29992626
Chiral resolution of [(14) C]ketamine and chiral column separation of [(14) C]norketamine resolved/separated the (S)-enantiomers from (R)-enantiomers....
Chiral resolution of [(14) C]ketamine and chiral column separation of [(14) C]norketamine resolved/separated the (S)-enantiomers from (R
Synthesis of carboxy-polyethylene glycol-amine (CA (PEG)n ) and [1-14 C]-CA (PEG)n via oxa-Michael addition of amino-polyethylene glycols to propiolates vs to acrylates.
Song F, Chen L, Lin R, Salter R. Song F, et al. Among authors: salter r. J Labelled Comp Radiopharm. 2020 Jan;63(1):15-24. doi: 10.1002/jlcr.3816. Epub 2019 Dec 13. J Labelled Comp Radiopharm. 2020. PMID: 31736118
Bio-generation of stable isotope labeled internal standards for absolute and relative quantitation of drug metabolites in plasma samples by LC-MS/MS.
Li P, Gong Y, Lim HK, Jian W, Edom RW, Salter R, Silva J, Weng N. Li P, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:92-100. doi: 10.1016/j.jchromb.2013.03.006. Epub 2013 Mar 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23562907
Transglycosylation in the Modification and Isotope Labeling of Pyrimidine Nucleosides.
Gong Y, Chen L, Zhang W, Salter R. Gong Y, et al. Among authors: salter r. Org Lett. 2020 Jul 17;22(14):5577-5581. doi: 10.1021/acs.orglett.0c01941. Epub 2020 Jul 6. Org Lett. 2020. PMID: 32628494
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease.
Rombouts FJ, Andrés JI, Ariza M, Alonso JM, Austin N, Bottelbergs A, Chen L, Chupakhin V, Cleiren E, Fierens K, Fontana A, Langlois X, Leenaerts JE, Mariën J, Martínez Lamenca C, Salter R, Schmidt ME, Te Riele P, Wintmolders C, Trabanco AA, Zhang W, Macdonald G, Moechars D. Rombouts FJ, et al. J Med Chem. 2017 Feb 23;60(4):1272-1291. doi: 10.1021/acs.jmedchem.6b01173. Epub 2017 Feb 10. J Med Chem. 2017. PMID: 28106992
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