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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1956 1
1957 1
1958 1
1959 2
1960 2
1961 2
1962 1
1963 1
1964 4
1965 6
1966 2
1967 4
1968 5
1969 4
1970 8
1971 1
1972 4
1973 6
1974 2
1975 5
1976 7
1977 5
1978 7
1979 1
1980 5
1981 3
1982 3
1983 3
1984 5
1985 9
1986 5
1987 6
1988 10
1989 20
1990 31
1991 30
1992 35
1993 34
1994 29
1995 49
1996 34
1997 38
1998 41
1999 29
2000 42
2001 66
2002 78
2003 57
2004 60
2005 85
2006 101
2007 111
2008 117
2009 98
2010 124
2011 146
2012 149
2013 150
2014 203
2015 227
2016 301
2017 325
2018 317
2019 379
2020 388
2021 477
2022 417
2023 395
2024 478
2025 569
2026 391

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5,921 results

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Page 1
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy.
Redondo-Muñoz M, Rodriguez-Baena FJ, Aldaz P, Caballé-Mestres A, Moncho-Amor V, Otaegi-Ugartemendia M, Carrasco-Garcia E, Olias-Arjona A, Lasheras-Otero I, Santamaria E, Bocanegra A, Chocarro L, Grier A, Dzieciatkowska M M, Bigas C, Martin J, Urdiroz-Urricelqui U, Marzo F, Santamaria E, Kochan G, Escors D, Larrayoz IM, Heyn H, D'Alessandro A, Attolini CS, Matheu A, Wellbrock C, Benitah SA, Sanchez-Laorden B, Arozarena I. Redondo-Muñoz M, et al. Nat Metab. 2023 Sep;5(9):1544-1562. doi: 10.1038/s42255-023-00861-4. Epub 2023 Aug 10. Nat Metab. 2023. PMID: 37563469 Free PMC article.
Moreover, by rewiring the methionine salvage pathway, RANO enhances melanoma immunogenicity through increased antigen presentation and interferon signalling. Combination of RANO with anti-PD-L1 antibodies strongly improves survival by increasing antitumour immune responses …
Moreover, by rewiring the methionine salvage pathway, RANO enhances melanoma immunogenicity through increased antigen presentation and inter …
Coupling PD-L1 Inhibition and Lysosomal Degradation: Innovative Anti-PD-L1 Peptides for NSCLC Immunotherapy.
Merlino F, Pagliara V, D'Amore VM, Polcaro G, Di Leva FS, Russomanno P, Brancaccio D, Donati G, Diakogiannaki I, Boccino I, Liguori L, Amato J, Marzano S, Saviano A, Mazzarella V, Plewka J, Seneci P, Arosio D, Maione F, Skalniak L, Pepe S, Di Maro S, Sabbatino F, Marinelli L. Merlino F, et al. J Med Chem. 2026 Mar 12;69(5):5477-5500. doi: 10.1021/acs.jmedchem.5c02586. Epub 2026 Feb 23. J Med Chem. 2026. PMID: 41729103
Antibodies targeting PD-1 and PD-L1 have achieved considerable success against various cancers, however their effectiveness is limited as both therapeutic and diagnostic tools. Meanwhile, small organic molecules and macrocyclic peptides are currently at various stag …
Antibodies targeting PD-1 and PD-L1 have achieved considerable success against various cancers, however their effectiveness is …
Efficacy and safety of daprodustat in patients on peritoneal dialysis in the ASCEND-D trial.
Dasgupta I, Meadowcroft AM, Bhatt PR, Acharya A, Aarup M, Correa-Rotter R, Gupta S, Kher VK, Neto OMV, Rastogi A, Ots-Rosenberg M, Rayner B, Wong MG, Shah S, Taft L, Singh AK. Dasgupta I, et al. Nephrol Dial Transplant. 2025 Jun 30;40(7):1332-1341. doi: 10.1093/ndt/gfae273. Nephrol Dial Transplant. 2025. PMID: 39817409 Free PMC article. Clinical Trial.
This subgroup analysis examined the efficacy and safety of daprodustat versus darbepoetin alfa in patients with anemia of CKD undergoing peritoneal dialysis (PD). METHODS: ASCEND-D (NCT02879305) was an open-label, Phase 3 trial; patients with CKD were randomized to daprodu …
This subgroup analysis examined the efficacy and safety of daprodustat versus darbepoetin alfa in patients with anemia of CKD undergoing per …
Cancer immunosurveillance by CD8 T cells.
Crispin JC, Tsokos GC. Crispin JC, et al. F1000Res. 2020 Feb 3;9:F1000 Faculty Rev-80. doi: 10.12688/f1000research.21150.1. eCollection 2020. F1000Res. 2020. PMID: 32089832 Free PMC article. Review.
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques.
Kauffman KD, Sakai S, Lora NE, Namasivayam S, Baker PJ, Kamenyeva O, Foreman TW, Nelson CE, Oliveira-de-Souza D, Vinhaes CL, Yaniv Z, Lindestam Arleham CS, Sette A, Freeman GJ, Moore R; NIAID/DIR Tuberculosis Imaging Program; Sher A, Mayer-Barber KD, Andrade BB, Kabat J, Via LE, Barber DL. Kauffman KD, et al. Sci Immunol. 2021 Jan 15;6(55):eabf3861. doi: 10.1126/sciimmunol.abf3861. Sci Immunol. 2021. PMID: 33452107 Free PMC article.
Boosting immune cell function by targeting the coinhibitory receptor PD-1 may have applications in the treatment of chronic infections. Here, we examine the role of PD-1 during Mycobacterium tuberculosis (Mtb) infection of rhesus macaques. ...PD-1 blockade in …
Boosting immune cell function by targeting the coinhibitory receptor PD-1 may have applications in the treatment of chronic infection …
PD-L1 testing in advanced gastric cancer-what physicians who treat this disease must know-a literature review.
Peixoto RD, Mathias-Machado MC, Jácome A, Gil M, Fogacci J, Sodré B, Passarini T, Chaves A, Diniz PH, Lino F, Palladino A, Souto M, de Castro AC, Garicochea B. Peixoto RD, et al. J Gastrointest Oncol. 2023 Jun 30;14(3):1560-1575. doi: 10.21037/jgo-22-1133. Epub 2023 May 11. J Gastrointest Oncol. 2023. PMID: 37435200 Free PMC article. Review.
METHODS: In the present comprehensive review, we revised the main studies regarding PD-L1 evaluation in GC. KEY CONTENT AND FINDINGS: Here we describe the molecular characteristics of the tumor microenvironment in GC, the obstacles in the interpretation of PD-L1 exp …
METHODS: In the present comprehensive review, we revised the main studies regarding PD-L1 evaluation in GC. KEY CONTENT AND FINDINGS: …
Anti-trypanosomal screening of Salvadoran flora.
Castillo UG, Komatsu A, Martínez ML, Menjívar J, Núñez MJ, Uekusa Y, Narukawa Y, Kiuchi F, Nakajima-Shimada J. Castillo UG, et al. J Nat Med. 2022 Jan;76(1):259-267. doi: 10.1007/s11418-021-01562-6. Epub 2021 Sep 16. J Nat Med. 2022. PMID: 34529189 Free PMC article.
Plants were selected through literature search for plants ethnobotanically used for antiparasitic and Chagas disease symptomatology, and reported in Museo de Historia Natural de El Salvador (MUHNES) database. T. cruzi was incubated for 72 h with 2 different concentrations …
Plants were selected through literature search for plants ethnobotanically used for antiparasitic and Chagas disease symptomatology, and rep …
Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients.
Arrieta O, Montes-Servín E, Hernandez-Martinez JM, Cardona AF, Casas-Ruiz E, Crispín JC, Motola D, Flores-Estrada D, Barrera L. Arrieta O, et al. Oncotarget. 2017 Oct 24;8(60):101994-102005. doi: 10.18632/oncotarget.22025. eCollection 2017 Nov 24. Oncotarget. 2017. PMID: 29254220 Free PMC article.
The primary objective was to assess OS according to PD-1, PD-L1, PD-L2 expression status on PBMCs and lymphocyte subsets. Our results indicate that the percentage of PD-L1(+)CD3(+), PD-L1(+)CD3(+)CD8(+) PD-L2(+)PBMCs, PD-L2(+)CD3(+ …
The primary objective was to assess OS according to PD-1, PD-L1, PD-L2 expression status on PBMCs and lymphocyte subset …
Botox in dermatology.
Khawaja HA, Hernandez-Perez E. Khawaja HA, et al. Int J Dermatol. 2001 May;40(5):311-7. doi: 10.1046/j.1365-4362.2001.01176.x. Int J Dermatol. 2001. PMID: 11554992 Review. No abstract available.
5,921 results