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The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.
Syntichaki P, Samara C, Tavernarakis N. Syntichaki P, et al. Curr Biol. 2005 Jul 12;15(13):1249-54. doi: 10.1016/j.cub.2005.05.057. Curr Biol. 2005. PMID: 16005300
Here we show that the function of the vacuolar H(+)-ATPase, a pump that acidifies lysosomes and other intracellular organelles, is essential for necrotic cell death in C. elegans. ...Thus, intracellular pH is an important modulator of necrosis in C. elegans. We prop …
Here we show that the function of the vacuolar H(+)-ATPase, a pump that acidifies lysosomes and other intracellular organelles, is essential …
Autophagy and cell death in Caenorhabditis elegans.
Samara C, Tavernarakis N. Samara C, et al. Curr Pharm Des. 2008;14(2):97-115. doi: 10.2174/138161208783378770. Curr Pharm Des. 2008. PMID: 18220822 Review.
Research in C. elegans has proven instrumental for the elucidation of the molecular mechanisms underlying both apoptotic and necrotic cell death. ...We survey the relevant findings in C. elegans and also consider the contribution of autophagy in cell death in other …
Research in C. elegans has proven instrumental for the elucidation of the molecular mechanisms underlying both apoptotic and necrotic …
Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans.
Artal-Sanz M, Samara C, Syntichaki P, Tavernarakis N. Artal-Sanz M, et al. J Cell Biol. 2006 Apr 24;173(2):231-9. doi: 10.1083/jcb.200511103. J Cell Biol. 2006. PMID: 16636145 Free PMC article.
Recent studies in the nematode Caenorhabditis elegans show that cytoplasmic acidification develops during necrosis and is required for cell death (Syntichaki, P., C. Samara, and N. Tavernarakis. 2005. Curr. Biol. 15:1249-1254). However, the origin of cytoplasmic aci …
Recent studies in the nematode Caenorhabditis elegans show that cytoplasmic acidification develops during necrosis and is required for cell …
Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans.
Samara C, Tavernarakis N. Samara C, et al. Ageing Res Rev. 2003 Oct;2(4):451-71. doi: 10.1016/s1568-1637(03)00032-1. Ageing Res Rev. 2003. PMID: 14522246 Review.
Evidence from investigations in C. elegans implicates deregulated proteolysis as one major determinant of cellular destruction in neurodegeneration and ageing, and suggests that the process depends critically on the activation of calcium-dependent, calpain proteases and ly …
Evidence from investigations in C. elegans implicates deregulated proteolysis as one major determinant of cellular destruction in neu …
Autophagy is required for necrotic cell death in Caenorhabditis elegans.
Samara C, Syntichaki P, Tavernarakis N. Samara C, et al. Cell Death Differ. 2008 Jan;15(1):105-12. doi: 10.1038/sj.cdd.4402231. Epub 2007 Sep 28. Cell Death Differ. 2008. PMID: 17901876
We find that excessive autophagosome formation is induced early during necrotic cell death in C. elegans. In addition, autophagy is required for necrotic cell death. ...
We find that excessive autophagosome formation is induced early during necrotic cell death in C. elegans. In addition, autophagy is r …
High-throughput in vivo genetic and drug screening using femtosecond laser nano-surgery, and microfluidics.
Rohde C, Gilleland C, Samara C, Zeng F, Yanik MF. Rohde C, et al. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2642. doi: 10.1109/IEMBS.2008.4649743. Conf Proc IEEE Eng Med Biol Soc. 2008. PMID: 19163246
We demonstrate microfluidic devices and imaging technologies for high-speed immobilization, cellular resolution imaging, and femtosecond laser micro-surgery of awake small-animals (C. elegans) for high-throughput in vivo genetic and drug screens on neural degeneration and …
We demonstrate microfluidic devices and imaging technologies for high-speed immobilization, cellular resolution imaging, and femtosecond las …
Regulation of autophagy by cytoplasmic p53.
Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G. Tasdemir E, et al. Nat Cell Biol. 2008 Jun;10(6):676-87. doi: 10.1038/ncb1730. Epub 2008 May 4. Nat Cell Biol. 2008. PMID: 18454141 Free PMC article.
Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration.
Samara C, Rohde CB, Gilleland CL, Norton S, Haggarty SJ, Yanik MF. Samara C, et al. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18342-7. doi: 10.1073/pnas.1005372107. Epub 2010 Oct 11. Proc Natl Acad Sci U S A. 2010. PMID: 20937901 Free PMC article.
Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration.
Rohde CB, Gilleland C, Samara C, Norton S, Haggarty S, Yanik MF. Rohde CB, et al. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:5950-2. doi: 10.1109/IEMBS.2009.5334771. Conf Proc IEEE Eng Med Biol Soc. 2009. PMID: 19965065
These screens are enabled by the microfluidic devices we have developed for C. elegans. The devices enable rapid and repeatable animal immobilization which allows high-throughput and precise surgery. ...
These screens are enabled by the microfluidic devices we have developed for C. elegans. The devices enable rapid and repeatable anima …
Giant somatosensory evoked potentials in children without myoclonic epilepsy.
Micheloyannis J, Samara C, Liakakos T. Micheloyannis J, et al. Acta Neurol Scand. 1989 Feb;79(2):146-9. doi: 10.1111/j.1600-0404.1989.tb03727.x. Acta Neurol Scand. 1989. PMID: 2496578
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