Sampson JR - Search Results

1

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.

Dodd KM, Yang J, Shen MH, Sampson JR, Tee AR. Dodd KM, et al. Among authors: sampson jr. Oncogene. 2015 Apr 23;34(17):2239-50. doi: 10.1038/onc.2014.164. Epub 2014 Jun 16. Oncogene. 2015. PMID: 24931163 Free PMC article.

2

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination.

Benvenuto G, Li S, Brown SJ, Braverman R, Vass WC, Cheadle JP, Halley DJ, Sampson JR, Wienecke R, DeClue JE. Benvenuto G, et al. Among authors: sampson jr. Oncogene. 2000 Dec 14;19(54):6306-16. doi: 10.1038/sj.onc.1204009. Oncogene. 2000. PMID: 11175345

3

Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence.

Dunlop EA, Dodd KM, Land SC, Davies PA, Martins N, Stuart H, McKee S, Kingswood C, Saggar A, Corderio I, Medeira AM, Kingston H, Sampson JR, Davies DM, Tee AR. Dunlop EA, et al. Among authors: sampson jr. Eur J Hum Genet. 2011 Jul;19(7):789-95. doi: 10.1038/ejhg.2011.38. Epub 2011 Mar 16. Eur J Hum Genet. 2011. PMID: 21407264 Free PMC article.

4

T2 weighted MRI for assessing renal lesions in transgenic mouse models of tuberous sclerosis.

Kalogerou M, Zhang Y, Yang J, Garrahan N, Paisey S, Tokarczuk P, Stewart A, Gallacher J, Sampson JR, Shen MH. Kalogerou M, et al. Among authors: sampson jr. Eur J Radiol. 2012 Sep;81(9):2069-74. doi: 10.1016/j.ejrad.2011.06.054. Epub 2011 Jul 28. Eur J Radiol. 2012. PMID: 21802234

5

Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.

Yang J, Kalogerou M, Gallacher J, Sampson JR, Shen MH. Yang J, et al. Among authors: sampson jr. Eur J Cancer. 2013 Apr;49(6):1479-90. doi: 10.1016/j.ejca.2012.10.027. Epub 2012 Dec 7. Eur J Cancer. 2013. PMID: 23228442

6

Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin.

Yang J, Kalogerou M, Samsel PA, Zhang Y, Griffiths DF, Gallacher J, Sampson JR, Shen MH. Yang J, et al. Among authors: sampson jr. Oncogene. 2015 Feb 12;34(7):922-31. doi: 10.1038/onc.2014.17. Epub 2014 Mar 17. Oncogene. 2015. PMID: 24632604

7

Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components.

Saxena A, Sampson JR. Saxena A, et al. Among authors: sampson jr. Semin Cell Dev Biol. 2014 Dec;36:140-6. doi: 10.1016/j.semcdb.2014.09.018. Epub 2014 Sep 27. Semin Cell Dev Biol. 2014. PMID: 25263008 Review.

8

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.

Johnson CE, Hunt DK, Wiltshire M, Herbert TP, Sampson JR, Errington RJ, Davies DM, Tee AR. Johnson CE, et al. Among authors: sampson jr. Mol Oncol. 2015 Mar;9(3):675-88. doi: 10.1016/j.molonc.2014.11.005. Epub 2014 Nov 22. Mol Oncol. 2015. PMID: 25498902 Free PMC article.

9

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex.

Tee AR, Sampson JR, Pal DK, Bateman JM. Tee AR, et al. Among authors: sampson jr. Semin Cell Dev Biol. 2016 Apr;52:12-20. doi: 10.1016/j.semcdb.2016.01.040. Epub 2016 Feb 2. Semin Cell Dev Biol. 2016. PMID: 26849906 Free PMC article. Review.

10

Combination of Everolimus with Sorafenib for Solid Renal Tumors in Tsc2^+/- Mice Is Superior to Everolimus Alone.

Yang J, Samsel PA, Narov K, Jones A, Gallacher D, Gallacher J, Sampson JR, Shen MH. Yang J, et al. Among authors: sampson jr. Neoplasia. 2017 Feb;19(2):112-120. doi: 10.1016/j.neo.2016.12.008. Epub 2017 Jan 13. Neoplasia. 2017. PMID: 28092822 Free PMC article.

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