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Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.
Taghavi N, Samuel CE. Taghavi N, et al. Virology. 2012 Jun 5;427(2):208-16. doi: 10.1016/j.virol.2012.01.029. Epub 2012 Mar 3. Virology. 2012. PMID: 22381929 Free PMC article.
Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon.
George CX, Das S, Samuel CE. George CX, et al. Virology. 2008 Oct 25;380(2):338-43. doi: 10.1016/j.virol.2008.07.029. Epub 2008 Sep 6. Virology. 2008. PMID: 18774582 Free PMC article.
Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis.
Zhang P, Jacobs BL, Samuel CE. Zhang P, et al. J Virol. 2008 Jan;82(2):840-8. doi: 10.1128/JVI.01891-07. Epub 2007 Oct 24. J Virol. 2008. PMID: 17959656 Free PMC article.
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
Li Z, Wolff KC, Samuel CE. Li Z, et al. Virology. 2010 Jan 20;396(2):316-22. doi: 10.1016/j.virol.2009.10.026. Epub 2009 Nov 12. Virology. 2010. PMID: 19913273 Free PMC article.
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR.
McMillan NA, Chun RF, Siderovski DP, Galabru J, Toone WM, Samuel CE, Mak TW, Hovanessian AG, Jeang KT, Williams BR. McMillan NA, et al. Virology. 1995 Nov 10;213(2):413-24. doi: 10.1006/viro.1995.0014. Virology. 1995. PMID: 7491766
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