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Oncogenic mutations of PIK3CA in human cancers.
Samuels Y, Velculescu VE. Samuels Y, et al. Cell Cycle. 2004 Oct;3(10):1221-4. doi: 10.4161/cc.3.10.1164. Epub 2004 Oct 12. Cell Cycle. 2004. PMID: 15467468
High frequency of mutations of the PIK3CA gene in human cancers.
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. Samuels Y, et al. Science. 2004 Apr 23;304(5670):554. doi: 10.1126/science.1096502. Epub 2004 Mar 11. Science. 2004. PMID: 15016963 No abstract available.
The PIK3CA gene is mutated with high frequency in human breast cancers.
Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, Peters BA, Velculescu VE, Park BH. Bachman KE, et al. Among authors: samuels y. Cancer Biol Ther. 2004 Aug;3(8):772-5. doi: 10.4161/cbt.3.8.994. Epub 2004 Aug 26. Cancer Biol Ther. 2004. PMID: 15254419
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.
Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, Fults DW, Velculescu VE, Bigner DD, Yan H. Broderick DK, et al. Among authors: samuels yr. Cancer Res. 2004 Aug 1;64(15):5048-50. doi: 10.1158/0008-5472.CAN-04-1170. Cancer Res. 2004. PMID: 15289301
Inhibiting phosphoinositide 3-kinases.
Samuels Y, Zhu J, Lengauer C. Samuels Y, et al. Cancer Biol Ther. 2005 May;4(5):546-7. doi: 10.4161/cbt.4.5.1669. Epub 2005 May 15. Cancer Biol Ther. 2005. PMID: 15908801 No abstract available.
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Samuels Y, Diaz LA Jr, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Samuels Y, et al. Cancer Cell. 2005 Jun;7(6):561-73. doi: 10.1016/j.ccr.2005.05.014. Cancer Cell. 2005. PMID: 15950905
Colorectal cancer: mutations in a signalling pathway.
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Parsons DW, et al. Among authors: samuels y. Nature. 2005 Aug 11;436(7052):792. doi: 10.1038/436792a. Nature. 2005. PMID: 16094359
Oncogenic PI3K and its role in cancer.
Samuels Y, Ericson K. Samuels Y, et al. Curr Opin Oncol. 2006 Jan;18(1):77-82. doi: 10.1097/01.cco.0000198021.99347.b9. Curr Opin Oncol. 2006. PMID: 16357568 Review.
Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms.
Nakayama K, Nakayama N, Kurman RJ, Cope L, Pohl G, Samuels Y, Velculescu VE, Wang TL, Shih IeM. Nakayama K, et al. Among authors: samuels y. Cancer Biol Ther. 2006 Jul;5(7):779-85. doi: 10.4161/cbt.5.7.2751. Epub 2006 Jul 26. Cancer Biol Ther. 2006. PMID: 16721043
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. Huang CH, et al. Among authors: samuels y. Science. 2007 Dec 14;318(5857):1744-8. doi: 10.1126/science.1150799. Science. 2007. PMID: 18079394
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