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The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.
Sanchez-Roman I, Gomez J, Naudi A, Ayala V, Portero-Otín M, Lopez-Torres M, Pamplona R, Barja G. Sanchez-Roman I, et al. Rejuvenation Res. 2010 Dec;13(6):683-93. doi: 10.1089/rej.2010.1062. Epub 2010 Sep 6. Rejuvenation Res. 2010. PMID: 20818929
Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity.
Gómez A, Sánchez-Roman I, Gomez J, Cruces J, Mate I, Lopez-Torres M, Naudi A, Portero-Otin M, Pamplona R, De la Fuente M, Barja G. Gómez A, et al. Among authors: sanchez roman i. Aging Cell. 2014 Jun;13(3):551-60. doi: 10.1111/acel.12205. Epub 2014 Feb 26. Aging Cell. 2014. PMID: 24612513 Free PMC article.