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cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function.
Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L. Jaumann M, et al. Among authors: sandner p. Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634. Nat Med. 2012. PMID: 22270721
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.
Follmann M, Ackerstaff J, Redlich G, Wunder F, Lang D, Kern A, Fey P, Griebenow N, Kroh W, Becker-Pelster EM, Kretschmer A, Geiss V, Li V, Straub A, Mittendorf J, Jautelat R, Schirok H, Schlemmer KH, Lustig K, Gerisch M, Knorr A, Tinel H, Mondritzki T, Trübel H, Sandner P, Stasch JP. Follmann M, et al. Among authors: sandner p. J Med Chem. 2017 Jun 22;60(12):5146-5161. doi: 10.1021/acs.jmedchem.7b00449. Epub 2017 Jun 12. J Med Chem. 2017. PMID: 28557445 Free article.
Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.
Potoka KP, Wood KC, Baust JJ, Bueno M, Hahn SA, Vanderpool RR, Bachman T, Mallampalli GM, Osei-Hwedieh DO, Schrott V, Sun B, Bullock GC, Becker-Pelster EM, Wittwer M, Stampfuss J, Mathar I, Stasch JP, Truebel H, Sandner P, Mora AL, Straub AC, Gladwin MT. Potoka KP, et al. Among authors: sandner p. Am J Respir Cell Mol Biol. 2018 May;58(5):636-647. doi: 10.1165/rcmb.2017-0292OC. Am J Respir Cell Mol Biol. 2018. PMID: 29268036 Free PMC article.
Nitric oxide-sensitive guanylyl cyclase stimulation improves experimental heart failure with preserved ejection fraction.
Wilck N, Markó L, Balogh A, Kräker K, Herse F, Bartolomaeus H, Szijártó IA, Gollasch M, Reichhart N, Strauss O, Heuser A, Brockschnieder D, Kretschmer A, Lesche R, Sohler F, Stasch JP, Sandner P, Luft FC, Müller DN, Dechend R, Haase N. Wilck N, et al. Among authors: sandner p. JCI Insight. 2018 Feb 22;3(4):e96006. doi: 10.1172/jci.insight.96006. eCollection 2018 Feb 22. JCI Insight. 2018. PMID: 29467337 Free PMC article.
Urinary cGMP predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus before exposure to contrast medium.
Chaykovska L, Heunisch F, von Einem G, Hocher CF, Tsuprykov O, Pavkovic M, Sandner P, Kretschmer A, Chu C, Elitok S, Stasch JP, Hocher B. Chaykovska L, et al. Among authors: sandner p. PLoS One. 2018 Apr 12;13(4):e0195828. doi: 10.1371/journal.pone.0195828. eCollection 2018. PLoS One. 2018. PMID: 29649334 Free PMC article.
Soluble Guanylate Cyclase Stimulators and Activators.
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A, Stasch JP. Sandner P, et al. Handb Exp Pharmacol. 2021;264:355-394. doi: 10.1007/164_2018_197. Handb Exp Pharmacol. 2021. PMID: 30689085
Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies.
Ferreira WA Jr, Chweih H, Lanaro C, Almeida CB, Brito PL, Gotardo EMF, Torres L, Miguel LI, Franco-Penteado CF, Leonardo FC, Garcia F, Saad STO, Frenette PS, Brockschnieder D, Costa FF, Stasch JP, Sandner P, Conran N. Ferreira WA Jr, et al. Among authors: sandner p. J Pharmacol Exp Ther. 2020 Sep;374(3):469-478. doi: 10.1124/jpet.119.264606. Epub 2020 Jul 6. J Pharmacol Exp Ther. 2020. PMID: 32631869 Free PMC article.
126 results