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A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro.
Knapman A, Santiago M, Connor M. Knapman A, et al. Among authors: santiago m. Br J Pharmacol. 2015 May;172(9):2258-72. doi: 10.1111/bph.13047. Epub 2015 Mar 17. Br J Pharmacol. 2015. PMID: 25521224 Free PMC article.
A continuous, fluorescence-based assay of μ-opioid receptor activation in AtT-20 cells.
Knapman A, Santiago M, Du YP, Bennallack PR, Christie MJ, Connor M. Knapman A, et al. Among authors: santiago m. J Biomol Screen. 2013 Mar;18(3):269-76. doi: 10.1177/1087057112461376. Epub 2012 Sep 26. J Biomol Screen. 2013. PMID: 23015017
Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.
Banister SD, Longworth M, Kevin R, Sachdev S, Santiago M, Stuart J, Mack JB, Glass M, McGregor IS, Connor M, Kassiou M. Banister SD, et al. Among authors: santiago m. ACS Chem Neurosci. 2016 Sep 21;7(9):1241-54. doi: 10.1021/acschemneuro.6b00137. Epub 2016 Jul 27. ACS Chem Neurosci. 2016. PMID: 27421060
Cannabichromene is a cannabinoid CB2 receptor agonist.
Udoh M, Santiago M, Devenish S, McGregor IS, Connor M. Udoh M, et al. Among authors: santiago m. Br J Pharmacol. 2019 Dec;176(23):4537-4547. doi: 10.1111/bph.14815. Epub 2019 Nov 21. Br J Pharmacol. 2019. PMID: 31368508
In vitro determination of the efficacy of illicit synthetic cannabinoids at CB1 receptors.
Sachdev S, Vemuri K, Banister SD, Longworth M, Kassiou M, Santiago M, Makriyannis A, Connor M. Sachdev S, et al. Among authors: santiago m. Br J Pharmacol. 2019 Dec;176(24):4653-4665. doi: 10.1111/bph.14829. Epub 2019 Dec 10. Br J Pharmacol. 2019. PMID: 31412133
Absence of Entourage: Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors.
Santiago M, Sachdev S, Arnold JC, McGregor IS, Connor M. Santiago M, et al. Cannabis Cannabinoid Res. 2019 Sep 23;4(3):165-176. doi: 10.1089/can.2019.0016. eCollection 2019. Cannabis Cannabinoid Res. 2019. PMID: 31559333 Free PMC article.
Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells.
Sachdev S, Boyd R, Grimsey NL, Santiago M, Connor M. Sachdev S, et al. Among authors: santiago m. PeerJ. 2019 Sep 25;7:e7733. doi: 10.7717/peerj.7733. eCollection 2019. PeerJ. 2019. PMID: 31579608 Free PMC article.
Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists.
Sachdev S, Banister SD, Santiago M, Bladen C, Kassiou M, Connor M. Sachdev S, et al. Among authors: santiago m. Pharmacol Res Perspect. 2020 Apr;8(2):e00566. doi: 10.1002/prp2.566. Pharmacol Res Perspect. 2020. PMID: 32101383 Free PMC article.
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.
Gillis A, Gondin AB, Kliewer A, Sanchez J, Lim HD, Alamein C, Manandhar P, Santiago M, Fritzwanker S, Schmiedel F, Katte TA, Reekie T, Grimsey NL, Kassiou M, Kellam B, Krasel C, Halls ML, Connor M, Lane JR, Schulz S, Christie MJ, Canals M. Gillis A, et al. Among authors: santiago m. Sci Signal. 2020 Mar 31;13(625):eaaz3140. doi: 10.1126/scisignal.aaz3140. Sci Signal. 2020. PMID: 32234959
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