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C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP
Carnevale R, et al. Sci Rep 2017. Among authors: Santulli M. PMID 28630469 Free PMC article.
C2238/αANP (10(-10) M) induced higher collagen-induced platelet aggregation with respect to both control without ANP and T2238/αANP. This effect was even stronger at a higher concentration (10(-6) M). Mechanistically, C2238/αANP significantly lowered platelet cAMP levels, increased ROS production and activated Nox2, with respect to both control and T2238/αANP. ...
C2238/αANP (10(-10) M) induced higher collagen-induced platelet aggregation with respect to both control without ANP and T2238/αANP. …
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