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Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.
Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. Saphire EO, et al. J Mol Biol. 2007 Jun 8;369(3):696-709. doi: 10.1016/j.jmb.2007.01.060. Epub 2007 Jan 27. J Mol Biol. 2007. PMID: 17445828 Free PMC article.
Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, MacRae IJ, Saphire EO. Kimberlin CR, et al. Among authors: Saphire EO. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):314-9. doi: 10.1073/pnas.0910547107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018665 Free PMC article.
Ebolavirus glycoprotein structure and mechanism of entry.
Lee JE, Saphire EO. Lee JE, et al. Among authors: Saphire EO. Future Virol. 2009;4(6):621-635. doi: 10.2217/fvl.09.56. Future Virol. 2009. PMID: 20198110 Free PMC article.
Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO. Hastie KM, et al. Among authors: Saphire EO. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2396-401. doi: 10.1073/pnas.1016404108. Epub 2011 Jan 24. Proc Natl Acad Sci U S A. 2011. PMID: 21262835 Free PMC article.
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