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Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation.
Sousa MM, Yan SD, Stern D, Saraiva MJ. Sousa MM, et al. Among authors: saraiva mj. Lab Invest. 2000 Jul;80(7):1101-10. doi: 10.1038/labinvest.3780116. Lab Invest. 2000. PMID: 10908156
Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia.
Gomes JR, Nogueira RS, Vieira M, Santos SD, Ferraz-Nogueira JP, Relvas JB, Saraiva MJ. Gomes JR, et al. Among authors: saraiva mj. Cell Death Differ. 2016 Nov 1;23(11):1749-1764. doi: 10.1038/cdd.2016.64. Epub 2016 Aug 12. Cell Death Differ. 2016. PMID: 27518433 Free PMC article.
Thyroid hormone distribution in the mouse brain: the role of transthyretin.
Palha JA, Nissanov J, Fernandes R, Sousa JC, Bertrand L, Dratman MB, Morreale de Escobar G, Gottesman M, Saraiva MJ. Palha JA, et al. Among authors: saraiva mj. Neuroscience. 2002;113(4):837-47. doi: 10.1016/s0306-4522(02)00228-2. Neuroscience. 2002. PMID: 12182890
5Alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway.
Quintela T, Alves CH, Gonçalves I, Baltazar G, Saraiva MJ, Santos CR. Quintela T, et al. Among authors: saraiva mj. Brain Res. 2008 Sep 10;1229:18-26. doi: 10.1016/j.brainres.2008.06.095. Epub 2008 Jul 2. Brain Res. 2008. PMID: 18634756
Transthyretin mutations in hyperthyroxinemia and amyloid diseases.
Saraiva MJ. Saraiva MJ. Hum Mutat. 2001 Jun;17(6):493-503. doi: 10.1002/humu.1132. Hum Mutat. 2001. PMID: 11385707 Review.
Genetic anticipation in Portuguese kindreds with familial amyloidotic polyneuropathy is unlikely to be caused by triplet repeat expansions.
Soares M, Buxbaum J, Sirugo G, Coelho T, Sousa A, Kastner D, Saraiva MJ. Soares M, et al. Among authors: saraiva mj. Hum Genet. 1999 Jun;104(6):480-5. doi: 10.1007/s004390050991. Hum Genet. 1999. PMID: 10453736
Structure of the Val122Ile variant transthyretin - a cardiomyopathic mutant.
Damas AM, Ribeiro S, Lamzin VS, Palha JA, Saraiva MJ. Damas AM, et al. Among authors: saraiva mj. Acta Crystallogr D Biol Crystallogr. 1996 Sep 1;52(Pt 5):966-72. doi: 10.1107/S0907444996003307. Acta Crystallogr D Biol Crystallogr. 1996. PMID: 15299606
Crystallization and preliminary X-ray diffraction studies of Leu55Pro variant transthyretin.
Sebastião P, Dauter Z, Saraiva MJ, Damas AM. Sebastião P, et al. Among authors: saraiva mj. Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):566-8. doi: 10.1107/S0907444995013965. Acta Crystallogr D Biol Crystallogr. 1996. PMID: 15299680
Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model.
Batista AR, Gianni D, Ventosa M, Coelho AV, Almeida MR, Sena-Esteves M, Saraiva MJ. Batista AR, et al. Among authors: saraiva mj. Gene Ther. 2014 Dec;21(12):1041-50. doi: 10.1038/gt.2014.86. Epub 2014 Oct 2. Gene Ther. 2014. PMID: 25273354
Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related.
Cardoso I, Brito M, Saraiva MJ. Cardoso I, et al. Among authors: saraiva mj. Dis Markers. 2008;25(1):37-47. doi: 10.1155/2008/549872. Dis Markers. 2008. PMID: 18776590 Free PMC article.
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