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The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems.
Santos SD, Fernandes R, Saraiva MJ. Santos SD, et al. Among authors: saraiva mj. Neurobiol Aging. 2010 Feb;31(2):280-9. doi: 10.1016/j.neurobiolaging.2008.04.001. Neurobiol Aging. 2010. PMID: 18485534
Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro.
Sousa MM, Fernandes R, Palha JA, Taboada A, Vieira P, Saraiva MJ. Sousa MM, et al. Among authors: saraiva mj. Am J Pathol. 2002 Nov;161(5):1935-48. doi: 10.1016/S0002-9440(10)64469-0. Am J Pathol. 2002. PMID: 12414539 Free PMC article.
X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization.
Gales L, Cardoso I, Fayard B, Quintanilha A, Saraiva MJ, Damas AM. Gales L, et al. Among authors: saraiva mj. J Biol Chem. 2003 Mar 28;278(13):11654-60. doi: 10.1074/jbc.M210798200. Epub 2003 Jan 21. J Biol Chem. 2003. PMID: 12538647
4'-iodo-4'-deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters.
Cardoso I, Merlini G, Saraiva MJ. Cardoso I, et al. Among authors: saraiva mj. FASEB J. 2003 May;17(8):803-9. doi: 10.1096/fj.02-0764com. FASEB J. 2003. PMID: 12724338
First Spanish family with familial amyloidotic polyneuropathy associated to TTR Thr49Ile mutation.
Saraiva MJ, Munar-Qués M, Modrego P, Moreira P, Viader-Farré C. Saraiva MJ, et al. Amyloid. 2003 Mar;10(1):34-5. doi: 10.3109/13506120308995255. Amyloid. 2003. PMID: 12762140
Cellular consequences of transthyretin deposition.
Saraiva MJ. Saraiva MJ. Amyloid. 2003 Aug;10 Suppl 1:13-6. Amyloid. 2003. PMID: 14640036 Review.
Haplotypes and DNA sequence variation within and surrounding the transthyretin gene: genotype-phenotype correlations in familial amyloid polyneuropathy (V30M) in Portugal and Sweden.
Soares ML, Coelho T, Sousa A, Holmgren G, Saraiva MJ, Kastner DL, Buxbaum JN. Soares ML, et al. Among authors: saraiva mj. Eur J Hum Genet. 2004 Mar;12(3):225-37. doi: 10.1038/sj.ejhg.5201095. Eur J Hum Genet. 2004. PMID: 14673473
Neurodegeneration in familial amyloid polyneuropathy: from pathology to molecular signaling.
Sousa MM, Saraiva MJ. Sousa MM, et al. Among authors: saraiva mj. Prog Neurobiol. 2003 Dec;71(5):385-400. doi: 10.1016/j.pneurobio.2003.11.002. Prog Neurobiol. 2003. PMID: 14757117 Review.
Transthyretin is involved in depression-like behaviour and exploratory activity.
Sousa JC, Grandela C, Fernández-Ruiz J, de Miguel R, de Sousa L, Magalhães AI, Saraiva MJ, Sousa N, Palha JA. Sousa JC, et al. Among authors: saraiva mj. J Neurochem. 2004 Mar;88(5):1052-8. doi: 10.1046/j.1471-4159.2003.02309.x. J Neurochem. 2004. PMID: 15009661
Transthyretin, a new cryptic protease.
Liz MA, Faro CJ, Saraiva MJ, Sousa MM. Liz MA, et al. Among authors: saraiva mj. J Biol Chem. 2004 May 14;279(20):21431-8. doi: 10.1074/jbc.M402212200. Epub 2004 Mar 19. J Biol Chem. 2004. PMID: 15033978
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