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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Sarbassov DD, et al. Curr Biol. 2004 Jul 27;14(14):1296-302. doi: 10.1016/j.cub.2004.06.054. Curr Biol. 2004. PMID: 15268862
Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D. Chen CH, et al. J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8. J Biol Chem. 2013. PMID: 23928304 Free PMC article.
Isolation of the mTOR complexes by affinity purification.
Sarbassov dos D, Bulgakova O, Bersimbaev RI, Shaiken T. Sarbassov dos D, et al. Methods Mol Biol. 2012;821:59-74. doi: 10.1007/978-1-61779-430-8_5. Methods Mol Biol. 2012. PMID: 22125060
The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.
Chen CH, Sarbassov dos D. Chen CH, et al. J Biol Chem. 2011 Nov 18;286(46):40386-94. doi: 10.1074/jbc.M111.282590. Epub 2011 Sep 30. J Biol Chem. 2011. PMID: 21965657 Free PMC article.
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.
Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M. Zeng Z, et al. Blood. 2007 Apr 15;109(8):3509-12. doi: 10.1182/blood-2006-06-030833. Epub 2006 Dec 19. Blood. 2007. PMID: 17179228 Free PMC article.
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.
Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Boulbes D, et al. Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25. Mol Cancer Res. 2010. PMID: 20501647 Free PMC article.
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Sarbassov DD, et al. Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148. Science. 2005. PMID: 15718470
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sarbassov dd. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sarbassov dd. Mol Cell. 2003 Apr;11(4):895-904. doi: 10.1016/s1097-2765(03)00114-x. Mol Cell. 2003. PMID: 12718876
Rictor regulates cell migration by suppressing RhoGDI2.
Agarwal NK, Chen CH, Cho H, Boulb├Ęs DR, Spooner E, Sarbassov DD. Agarwal NK, et al. Among authors: sarbassov dd. Oncogene. 2013 May 16;32(20):2521-6. doi: 10.1038/onc.2012.287. Epub 2012 Jul 9. Oncogene. 2013. PMID: 22777355 Free PMC article.
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