Sargent JL - Search Results

1

PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis.

Wei J, Ghosh AK, Sargent JL, Komura K, Wu M, Huang QQ, Jain M, Whitfield ML, Feghali-Bostwick C, Varga J. Wei J, et al. Among authors: sargent jl. PLoS One. 2010 Nov 2;5(11):e13778. doi: 10.1371/journal.pone.0013778. PLoS One. 2010. PMID: 21072170 Free PMC article.

2

Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis.

Bhattacharyya S, Sargent JL, Du P, Lin S, Tourtellotte WG, Takehara K, Whitfield ML, Varga J. Bhattacharyya S, et al. Among authors: sargent jl. PLoS One. 2011;6(9):e23082. doi: 10.1371/journal.pone.0023082. Epub 2011 Sep 13. PLoS One. 2011. PMID: 21931594 Free PMC article.

3

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.

Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J. Wei J, et al. Among authors: sargent jl. Arthritis Rheum. 2012 Aug;64(8):2734-45. doi: 10.1002/art.34424. Arthritis Rheum. 2012. PMID: 22328118 Free PMC article.

4

Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.

Johnson ME, Mahoney JM, Taroni J, Sargent JL, Marmarelis E, Wu MR, Varga J, Hinchcliff ME, Whitfield ML. Johnson ME, et al. Among authors: sargent jl. PLoS One. 2015 Jan 21;10(1):e0114017. doi: 10.1371/journal.pone.0114017. eCollection 2015. PLoS One. 2015. PMID: 25607805 Free PMC article. Clinical Trial.

5

Molecular subsets in the gene expression signatures of scleroderma skin.

Milano A, Pendergrass SA, Sargent JL, George LK, McCalmont TH, Connolly MK, Whitfield ML. Milano A, et al. Among authors: sargent jl. PLoS One. 2008 Jul 16;3(7):e2696. doi: 10.1371/journal.pone.0002696. PLoS One. 2008. PMID: 18648520 Free PMC article.

6

Capturing the heterogeneity in systemic sclerosis with genome-wide expression profiling.

Sargent JL, Whitfield ML. Sargent JL, et al. Expert Rev Clin Immunol. 2011 Jul;7(4):463-73. doi: 10.1586/eci.11.41. Expert Rev Clin Immunol. 2011. PMID: 21790289 Free PMC article. Review.

7

Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics.

Sargent JL, Li Z, Aliprantis AO, Greenblatt M, Lemaire R, Wu MH, Wei J, Taroni J, Harris A, Long KB, Burgwin C, Artlett CM, Blankenhorn EP, Lafyatis R, Varga J, Clark SH, Whitfield ML. Sargent JL, et al. Arthritis Rheumatol. 2016 Aug;68(8):2003-15. doi: 10.1002/art.39658. Arthritis Rheumatol. 2016. PMID: 26945694 Free PMC article.

8

A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity.

Sargent JL, Milano A, Bhattacharyya S, Varga J, Connolly MK, Chang HY, Whitfield ML. Sargent JL, et al. J Invest Dermatol. 2010 Mar;130(3):694-705. doi: 10.1038/jid.2009.318. Epub 2009 Oct 8. J Invest Dermatol. 2010. PMID: 19812599 Free PMC article.

9

Scleroderma gene expression and pathway signatures.

Sargent JL, Milano A, Connolly MK, Whitfield ML. Sargent JL, et al. Curr Rheumatol Rep. 2008 Jul;10(3):205-11. doi: 10.1007/s11926-008-0034-5. Curr Rheumatol Rep. 2008. PMID: 18638428 Review.

10

Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets.

Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO. Greenblatt MB, et al. Among authors: sargent jl. Am J Pathol. 2012 Mar;180(3):1080-1094. doi: 10.1016/j.ajpath.2011.11.024. Epub 2012 Jan 11. Am J Pathol. 2012. PMID: 22245215 Free PMC article.

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