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Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy.
Davies JE, Sarkar S, Rubinsztein DC. Davies JE, et al. Hum Mol Genet. 2006 Jan 1;15(1):23-31. doi: 10.1093/hmg/ddi422. Epub 2005 Nov 25. Hum Mol Genet. 2006. PMID: 16311254
The chemical chaperone trehalose has been used effectively to alleviate symptoms in a mouse model of Huntington's disease and is thought to elicit its effect by binding and stabilizing partially folded polyglutamine proteins and inhibiting the formation of aggregates. ...
The chemical chaperone trehalose has been used effectively to alleviate symptoms in a mouse model of Huntington's disease and is thou …
Lithium induces autophagy by inhibiting inositol monophosphatase.
Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. Sarkar S, et al. J Cell Biol. 2005 Sep 26;170(7):1101-11. doi: 10.1083/jcb.200504035. J Cell Biol. 2005. PMID: 16186256 Free PMC article.
This novel pharmacologic strategy for autophagy induction is independent of mTOR, and may help treatment of neurodegenerative diseases, like Huntington's disease, where the toxic protein is an autophagy substrate....
This novel pharmacologic strategy for autophagy induction is independent of mTOR, and may help treatment of neurodegenerative diseases, like …
Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations.
Sarkar S, Rubinsztein DC. Sarkar S, et al. Autophagy. 2006 Apr-Jun;2(2):132-4. doi: 10.4161/auto.2387. Epub 2006 Apr 6. Autophagy. 2006. PMID: 16874097 Review.
Induction of autophagy by lithium led to enhanced clearance of autophagy substrates, like mutant huntingtin fragments and mutant alpha-synucleins, associated with Huntington's disease (HD) and some autosomal dominant forms of Parkinson's disease (PD), respectively. …
Induction of autophagy by lithium led to enhanced clearance of autophagy substrates, like mutant huntingtin fragments and mutant alpha-synuc …
Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.
Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC. Williams A, et al. Curr Top Dev Biol. 2006;76:89-101. doi: 10.1016/S0070-2153(06)76003-3. Curr Top Dev Biol. 2006. PMID: 17118264 Review.
These include Alzheimer's disease, Parkinson's disease, tauopathies, and polyglutamine expansion diseases [e.g., Huntington's disease; and various spinocerebellar ataxias (SCAs), like SCA3]. ...We extended the range of intracellular proteinopathy substrates t …
These include Alzheimer's disease, Parkinson's disease, tauopathies, and polyglutamine expansion diseases [e.g., Huntington' …
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8. doi: 10.1038/nchembio883. Epub 2007 May 7. Nat Chem Biol. 2007. PMID: 17486044 Free PMC article.
Three SMERs induced autophagy independently of rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respecti …
Three SMERs induced autophagy independently of rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant …
Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.
Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC. Floto RA, et al. Autophagy. 2007 Nov-Dec;3(6):620-2. doi: 10.4161/auto.4898. Epub 2007 Aug 16. Autophagy. 2007. PMID: 17786022
Upregulation of autophagy may have therapeutic benefit in a range of diseases that includes neurodegenerative conditions caused by intracytosolic aggregate-prone proteins, such as Huntington's disease, and certain infectious diseases, such as tuberculosis. ...Next we showe …
Upregulation of autophagy may have therapeutic benefit in a range of diseases that includes neurodegenerative conditions caused by intracyto …
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. Sarkar S, et al. Hum Mol Genet. 2008 Jan 15;17(2):170-8. doi: 10.1093/hmg/ddm294. Epub 2007 Oct 6. Hum Mol Genet. 2008. PMID: 17921520
Huntington's disease (HD) is caused by a polyglutamine expansion mutation in the huntingtin protein that confers a toxic gain-of-function and causes the protein to become aggregate-prone. ...
Huntington's disease (HD) is caused by a polyglutamine expansion mutation in the huntingtin protein that confers a toxic gain-of-func …
Hydrophilic protein associated with desiccation tolerance exhibits broad protein stabilization function.
Chakrabortee S, Boschetti C, Walton LJ, Sarkar S, Rubinsztein DC, Tunnacliffe A. Chakrabortee S, et al. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18073-8. doi: 10.1073/pnas.0706964104. Epub 2007 Nov 2. Proc Natl Acad Sci U S A. 2007. PMID: 17984052 Free PMC article.
The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias.
Davies JE, Sarkar S, Rubinsztein DC. Davies JE, et al. BMC Biochem. 2007 Nov 22;8 Suppl 1(Suppl 1):S2. doi: 10.1186/1471-2091-8-S1-S2. BMC Biochem. 2007. PMID: 18047739 Free PMC article. Review.
Huntington's disease and several of the spinocerebellar ataxias are caused by the abnormal expansion of a CAG repeat within the coding region of the disease gene. ...Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www …
Huntington's disease and several of the spinocerebellar ataxias are caused by the abnormal expansion of a CAG repeat within the codin …
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