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Bacillus subtilis PrsA is required in vivo as an extracytoplasmic chaperone for secretion of active enzymes synthesized either with or without pro-sequences.
Jacobs M, Andersen JB, Kontinen V, Sarvas M. Jacobs M, et al. Mol Microbiol. 1993 May;8(5):957-66. doi: 10.1111/j.1365-2958.1993.tb01640.x. Mol Microbiol. 1993. PMID: 8102773
Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N- and C-terminal domains in protein folding and secretion in Bacillus subtilis.
Vitikainen M, Lappalainen I, Seppala R, Antelmann H, Boer H, Taira S, Savilahti H, Hecker M, Vihinen M, Sarvas M, Kontinen VP. Vitikainen M, et al. J Biol Chem. 2004 Apr 30;279(18):19302-14. doi: 10.1074/jbc.M400861200. Epub 2004 Feb 19. J Biol Chem. 2004. PMID: 14976191
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
Hyyryläinen HL, Sarvas M, Kontinen VP. Hyyryläinen HL, et al. Among authors: sarvas m. Appl Microbiol Biotechnol. 2005 May;67(3):389-96. doi: 10.1007/s00253-005-1898-1. Epub 2005 Jan 27. Appl Microbiol Biotechnol. 2005. PMID: 15856219
Secretion of heterologous proteins in Bacillus subtilis can be improved by engineering cell components affecting post-translocational protein folding and degradation.
Vitikainen M, Hyyryläinen HL, Kivimäki A, Kontinen VP, Sarvas M. Vitikainen M, et al. Among authors: sarvas m. J Appl Microbiol. 2005;99(2):363-75. doi: 10.1111/j.1365-2672.2005.02572.x. J Appl Microbiol. 2005. PMID: 16033468 Free article.
Ecs, an ABC transporter of Bacillus subtilis: dual signal transduction functions affecting expression of secreted proteins as well as their secretion.
Leskelä S, Wahlström E, Hyyryläinen HL, Jacobs M, Palva A, Sarvas M, Kontinen VP. Leskelä S, et al. Mol Microbiol. 1999 Jan;31(2):533-43. doi: 10.1046/j.1365-2958.1999.01194.x. Mol Microbiol. 1999. PMID: 10027970
Protein secretion in bacilli.
Sarvas M. Sarvas M. Curr Top Microbiol Immunol. 1986;125:103-25. doi: 10.1007/978-3-642-71251-7_8. Curr Top Microbiol Immunol. 1986. PMID: 3091323 Review. No abstract available.
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
Hyyryläinen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Prágai Z, Bron S, van Dijl JM, Kontinen VP. Hyyryläinen HL, et al. Mol Microbiol. 2001 Sep;41(5):1159-72. doi: 10.1046/j.1365-2958.2001.02576.x. Mol Microbiol. 2001. PMID: 11555295
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