Sathasivam K - Search Results

1

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ. Dalrymple A, et al. Among authors: sathasivam k. J Proteome Res. 2007 Jul;6(7):2833-40. doi: 10.1021/pr0700753. Epub 2007 Jun 7. J Proteome Res. 2007. PMID: 17552550

2

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.

Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP. Mangiarini L, et al. Among authors: sathasivam k. Cell. 1996 Nov 1;87(3):493-506. doi: 10.1016/s0092-8674(00)81369-0. Cell. 1996. PMID: 8898202 Free article.

3

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

Mangiarini L, Sathasivam K, Mahal A, Mott R, Seller M, Bates GP. Mangiarini L, et al. Among authors: sathasivam k. Nat Genet. 1997 Feb;15(2):197-200. doi: 10.1038/ng0297-197. Nat Genet. 1997. PMID: 9020849

4

Formation of polyglutamine inclusions in non-CNS tissue.

Sathasivam K, Hobbs C, Turmaine M, Mangiarini L, Mahal A, Bertaux F, Wanker EE, Doherty P, Davies SW, Bates GP. Sathasivam K, et al. Hum Mol Genet. 1999 May;8(5):813-22. doi: 10.1093/hmg/8.5.813. Hum Mol Genet. 1999. PMID: 10196370

5

Transgenic models of Huntington's disease.

Sathasivam K, Hobbs C, Mangiarini L, Mahal A, Turmaine M, Doherty P, Davies SW, Bates GP. Sathasivam K, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):963-9. doi: 10.1098/rstb.1999.0447. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10434294 Free PMC article. Review.

6

Detection of polyglutamine aggregation in mouse models.

Davies SW, Sathasivam K, Hobbs C, Doherty P, Mangiarini L, Scherzinger E, Wanker EE, Bates GP. Davies SW, et al. Among authors: sathasivam k. Methods Enzymol. 1999;309:687-701. doi: 10.1016/s0076-6879(99)09045-x. Methods Enzymol. 1999. PMID: 10507055 No abstract available.

7

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients.

Sathasivam K, Woodman B, Mahal A, Bertaux F, Wanker EE, Shima DT, Bates GP. Sathasivam K, et al. Hum Mol Genet. 2001 Oct 1;10(21):2425-35. doi: 10.1093/hmg/10.21.2425. Hum Mol Genet. 2001. PMID: 11689489

8

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.

Hockly E, Richon VM, Woodman B, Smith DL, Zhou X, Rosa E, Sathasivam K, Ghazi-Noori S, Mahal A, Lowden PA, Steffan JS, Marsh JL, Thompson LM, Lewis CM, Marks PA, Bates GP. Hockly E, et al. Among authors: sathasivam k. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6. doi: 10.1073/pnas.0437870100. Epub 2003 Feb 7. Proc Natl Acad Sci U S A. 2003. PMID: 12576549 Free PMC article.

9

Minocycline and doxycycline are not beneficial in a model of Huntington's disease.

Smith DL, Woodman B, Mahal A, Sathasivam K, Ghazi-Noori S, Lowden PA, Bates GP, Hockly E. Smith DL, et al. Among authors: sathasivam k. Ann Neurol. 2003 Aug;54(2):186-96. doi: 10.1002/ana.10614. Ann Neurol. 2003. PMID: 12891671

10

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach.

Hay DG, Sathasivam K, Tobaben S, Stahl B, Marber M, Mestril R, Mahal A, Smith DL, Woodman B, Bates GP. Hay DG, et al. Among authors: sathasivam k. Hum Mol Genet. 2004 Jul 1;13(13):1389-405. doi: 10.1093/hmg/ddh144. Epub 2004 Apr 28. Hum Mol Genet. 2004. PMID: 15115766

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