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Effects of ethanol and phenobarbital administration on the metabolism and toxicity of benzene.
Nakajima T, Okuyama S, Yonekura I, Sato A. Nakajima T, et al. Among authors: sato a. Chem Biol Interact. 1985 Oct;55(1-2):23-38. doi: 10.1016/s0009-2797(85)80118-6. Chem Biol Interact. 1985. PMID: 4064192
Again, PB-treatment produced only a negligible effect on the metabolism of benzene. Ethanol consumption aggravated benzene-induced hemopoietic disorder as evidenced by a marked decrease in the peripheral white blood cell number. PB produced a protective effec …
Again, PB-treatment produced only a negligible effect on the metabolism of benzene. Ethanol consumption aggravated benzene-induced he …
Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.
Sato A, Nakajima T, Koyama Y. Sato A, et al. Br J Ind Med. 1980 Nov;37(4):382-6. doi: 10.1136/oem.37.4.382. Br J Ind Med. 1980. PMID: 7192567 Free PMC article.
Although the ethanol feeding produced only a slight increase in the microsomal cytochrome P-450 content, it increased the in-vitro metabolism of most hydrocarbons three-to six-fold. ...A metabolism study using toluene as a model substrate indicated that chron …
Although the ethanol feeding produced only a slight increase in the microsomal cytochrome P-450 content, it increased the in-vitro me …
Kinetic studies on benzene metabolism in rat liver--possible presence of three forms of benzene metabolizing enzymes in the liver.
Nakajima T, Okino T, Sato A. Nakajima T, et al. Among authors: sato a. Biochem Pharmacol. 1987 Sep 1;36(17):2799-804. doi: 10.1016/0006-2952(87)90268-1. Biochem Pharmacol. 1987. PMID: 3632707
The kinetic analysis suggested that the liver of normally-fed rats contained two forms of benzene hydroxylases each with a Km value of 0.01 mM or 0.07 mM. The isozyme with a Km of 0.01 mM disappeared following one-day food deprivation, but the deprivation enhanced t …
The kinetic analysis suggested that the liver of normally-fed rats contained two forms of benzene hydroxylases each with a Km value o …
Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study.
Sato A, Nakajima T. Sato A, et al. Xenobiotica. 1985 Jan;15(1):67-75. doi: 10.3109/00498258509045336. Xenobiotica. 1985. PMID: 3920836
Although causing a marked increase both in microsomal protein and cytochrome p-450 contents, PB (80 mg/kg per day for three days) and PCB (a single dose of 500 mg/kg) induced only a limited range of enzyme activity: PB increased the metabolism of toluene, sty …
Although causing a marked increase both in microsomal protein and cytochrome p-450 contents, PB (80 mg/kg per day for three days) and …
Interaction between ethanol and carbohydrate on the metabolism in rat liver of aromatic and chlorinated hydrocarbons.
Sato A, Nakajima T, Koyama Y. Sato A, et al. Toxicol Appl Pharmacol. 1983 Apr;68(2):242-9. doi: 10.1016/0041-008x(83)90008-x. Toxicol Appl Pharmacol. 1983. PMID: 6857662
A decrease (increase) in carbohydrate intake augmented (suppressed) the action of ethanol in a dose-related manner. In particular, a combination of ethanol with a low-carbohydrate diet (DeCarli and Lieber diet) enhanced enzyme activity and potentiated
A decrease (increase) in carbohydrate intake augmented (suppressed) the action of ethanol in a dose-related manner. In particu
Augmentation of ethanol-induced enhancement of dimethylnitrosamine and diethylnitrosamine metabolism by lowered carbohydrate intake.
Sato A, Yonekura I, Asakawa M, Nakahara H, Nakajima T, Ohta S, Shirai T, Ito N. Sato A, et al. Jpn J Cancer Res. 1986 Feb;77(2):125-30. Jpn J Cancer Res. 1986. PMID: 3082824
It was confirmed by a Salmonella mutagenicity test that the enhancement of DMN and DEN metabolism was accompanied by increased capacity of the liver to activate these nitrosamines to mutagens. ...Ethanol combined with a diet deficient in CHO even suppressed the meta …
It was confirmed by a Salmonella mutagenicity test that the enhancement of DMN and DEN metabolism was accompanied by increased capaci …
[Effects of carbohydrate intake on phenobarbital-, polychlorinated biphenyl- and 3-methylcholanthrene-induced enhancement of drug oxidation and conjugation in rat liver].
Nakajima T, Sato A. Nakajima T, et al. Among authors: sato a. Nihon Eiseigaku Zasshi. 1984 Oct;39(4):779-86. doi: 10.1265/jjh.39.779. Nihon Eiseigaku Zasshi. 1984. PMID: 6441048 Japanese. No abstract available.
Dietary carbohydrate-and ethanol-induced alteration of the metabolism and toxicity of chemical substances.
Sato A, Nakajima T. Sato A, et al. Nutr Cancer. 1984;6(2):121-32. Nutr Cancer. 1984. PMID: 6400176 Review.
This paper is a review of experimental data leading to three main conclusions: Food deprivation causes a 2- to 3-fold increase in the metabolism of various chemicals in rat liver, such as chloroform and carbon tetrachloride. ...A decrease (increase) in carboh …
This paper is a review of experimental data leading to three main conclusions: Food deprivation causes a 2- to 3-fold increase …
Effect of carbohydrate intake on phenobarbital-, polychlorinated biphenyl- and 3-methylcholanthrene-induced enhancement of drug oxidation in rat liver.
Nakajima T, Sato A. Nakajima T, et al. Among authors: sato a. Biochem Pharmacol. 1984 Aug 1;33(15):2517-9. doi: 10.1016/0006-2952(84)90727-5. Biochem Pharmacol. 1984. PMID: 6431983 No abstract available.
Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons.
Sato A, Nakajima T, Koyama Y. Sato A, et al. Toxicol Appl Pharmacol. 1981 Aug;60(1):8-15. doi: 10.1016/0041-008x(81)90129-0. Toxicol Appl Pharmacol. 1981. PMID: 7281179 No abstract available.
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