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Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice.
Takei K, Han SI, Murayama Y, Satoh A, Oikawa F, Ohno H, Osaki Y, Matsuzaka T, Sekiya M, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Yamada N, Nakagawa Y, Shimano H. Takei K, et al. Among authors: satoh a. J Diabetes Investig. 2017 Jul;8(4):446-452. doi: 10.1111/jdi.12621. Epub 2017 Apr 25. J Diabetes Investig. 2017. PMID: 28084058 Free PMC article.
CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.
Nakagawa Y, Satoh A, Tezuka H, Han SI, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: satoh a. Sci Rep. 2016 Dec 16;6:39182. doi: 10.1038/srep39182. Sci Rep. 2016. PMID: 27982131 Free PMC article.
Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.
Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H. Fujimoto Y, et al. Among authors: satoh a. Biochem Biophys Res Commun. 2012 Apr 20;420(4):931-6. doi: 10.1016/j.bbrc.2012.03.110. Epub 2012 Mar 26. Biochem Biophys Res Commun. 2012. PMID: 22475483
TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis.
Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H. Fujimoto Y, et al. Among authors: satoh a. Endocrinology. 2013 Oct;154(10):3577-88. doi: 10.1210/en.2013-1203. Epub 2013 Jul 24. Endocrinology. 2013. PMID: 23885019
Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: satoh a. Endocrinology. 2014 Dec;155(12):4706-19. doi: 10.1210/en.2014-1113. Epub 2014 Sep 18. Endocrinology. 2014. PMID: 25233440
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system.
Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han SI, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: satoh a. Sci Rep. 2016 Jun 13;6:27857. doi: 10.1038/srep27857. Sci Rep. 2016. PMID: 27291420 Free PMC article.
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.
Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H. Kikuchi T, et al. Among authors: satoh a. Mol Metab. 2016 Sep 17;5(11):1092-1102. doi: 10.1016/j.molmet.2016.09.004. eCollection 2016 Nov. Mol Metab. 2016. PMID: 27818935 Free PMC article.
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.
Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H. Ohno H, et al. Among authors: satoh a. Endocrinology. 2018 Jun 1;159(6):2308-2323. doi: 10.1210/en.2017-03179. Endocrinology. 2018. PMID: 29668871
782 results