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De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder.
Hamilton PJ, Campbell NG, Sharma S, Erreger K, Herborg Hansen F, Saunders C, Belovich AN; NIH ARRA Autism Sequencing Consortium; Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A. Hamilton PJ, et al. Among authors: saunders c. Mol Psychiatry. 2013 Dec;18(12):1315-23. doi: 10.1038/mp.2013.102. Epub 2013 Aug 27. Mol Psychiatry. 2013. PMID: 23979605 Free PMC article.
PI3K signaling supports amphetamine-induced dopamine efflux.
Lute BJ, Khoshbouei H, Saunders C, Sen N, Lin RZ, Javitch JA, Galli A. Lute BJ, et al. Among authors: saunders c. Biochem Biophys Res Commun. 2008 Aug 8;372(4):656-61. doi: 10.1016/j.bbrc.2008.05.091. Epub 2008 May 27. Biochem Biophys Res Commun. 2008. PMID: 18510945 Free PMC article.
Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.
Bowton E, Saunders C, Erreger K, Sakrikar D, Matthies HJ, Sen N, Jessen T, Colbran RJ, Caron MG, Javitch JA, Blakely RD, Galli A. Bowton E, et al. Among authors: saunders c. J Neurosci. 2010 Apr 28;30(17):6048-57. doi: 10.1523/JNEUROSCI.5094-09.2010. J Neurosci. 2010. PMID: 20427663 Free PMC article.
Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding.
Speed N, Saunders C, Davis AR, Owens WA, Matthies HJ, Saadat S, Kennedy JP, Vaughan RA, Neve RL, Lindsley CW, Russo SJ, Daws LC, Niswender KD, Galli A. Speed N, et al. Among authors: saunders c. PLoS One. 2011;6(9):e25169. doi: 10.1371/journal.pone.0025169. Epub 2011 Sep 28. PLoS One. 2011. PMID: 21969871 Free PMC article.
Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function.
Saunders C, Siuta M, Robertson SD, Davis AR, Sauer J, Matthies HJG, Gresch PJ, Airey D, Lindsley CW, Schetz JA, Niswender KD, Veenstra-Vanderweele JM, Galli A. Saunders C, et al. Neurochem Int. 2014 Jul;73:113-121. doi: 10.1016/j.neuint.2013.09.015. Epub 2013 Sep 30. Neurochem Int. 2014. PMID: 24090638 Free PMC article.
Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.
Cartier E, Hamilton PJ, Belovich AN, Shekar A, Campbell NG, Saunders C, Andreassen TF, Gether U, Veenstra-Vanderweele J, Sutcliffe JS, Ulery-Reynolds PG, Erreger K, Matthies HJ, Galli A. Cartier E, et al. Among authors: saunders c. EBioMedicine. 2015 Feb;2(2):135-146. doi: 10.1016/j.ebiom.2015.01.007. EBioMedicine. 2015. PMID: 25774383 Free PMC article.
1,354 results