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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.
Losiewicz MD, Carlson BA, Kaur G, Sausville EA, Worland PJ. Losiewicz MD, et al. Among authors: sausville ea. Biochem Biophys Res Commun. 1994 Jun 15;201(2):589-95. doi: 10.1006/bbrc.1994.1742. Biochem Biophys Res Commun. 1994. PMID: 8002990
Different early effets of tyrphostin AG957 and geldanamycins on mitogen-activated protein kinase and p120cbl phosphorylation in anti CD-3-stimulated T-lymphoblasts.
Losiewicz MD, Kaur G, Sausville EA. Losiewicz MD, et al. Among authors: sausville ea. Biochem Pharmacol. 1999 Feb 1;57(3):281-9. doi: 10.1016/s0006-2952(98)00293-7. Biochem Pharmacol. 1999. PMID: 9890555
AG957, a tyrphostin tyrosine kinase inhibitor, has been shown previously to inhibit p210(bcr-abl) phosphorylation with concurrent inhibition of p210(bcr-abl)-expressing K562 cell growth (Kaur G and Sausville EA, Anticancer Drugs 7: 815-824, 1996). To assess the spec …
AG957, a tyrphostin tyrosine kinase inhibitor, has been shown previously to inhibit p210(bcr-abl) phosphorylation with concurrent inhibition …
DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells.
Nieves-Neira W, Rivera MI, Kohlhagen G, Hursey ML, Pourquier P, Sausville EA, Pommier Y. Nieves-Neira W, et al. Among authors: sausville ea. Mol Pharmacol. 1999 Sep;56(3):478-84. doi: 10.1124/mol.56.3.478. Mol Pharmacol. 1999. PMID: 10462535
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
De Azevedo WF Jr, Mueller-Dieckmann HJ, Schulze-Gahmen U, Worland PJ, Sausville E, Kim SH. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40. doi: 10.1073/pnas.93.7.2735. Proc Natl Acad Sci U S A. 1996. PMID: 8610110 Free PMC article.
P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228.
Sandor V, Senderowicz A, Mertins S, Sackett D, Sausville E, Blagosklonny MV, Bates SE. Sandor V, et al. Br J Cancer. 2000 Sep;83(6):817-25. doi: 10.1054/bjoc.2000.1327. Br J Cancer. 2000. PMID: 10952788 Free PMC article.
FR901228 causes mitotic arrest but does not alter microtubule polymerization.
Sandor V, Robbins AR, Robey R, Myers T, Sausville E, Bates SE, Sackett DL. Sandor V, et al. Anticancer Drugs. 2000 Jul;11(6):445-54. doi: 10.1097/00001813-200007000-00005. Anticancer Drugs. 2000. PMID: 11001385
Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy.
Sedlacek H, Czech J, Naik R, Kaur G, Worland P, Losiewicz M, Parker B, Carlson B, Smith A, Senderowicz A, Sausville E. Sedlacek H, et al. Int J Oncol. 1996 Dec;9(6):1143-68. doi: 10.3892/ijo.9.6.1143. Int J Oncol. 1996. PMID: 21541623
DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells.
Meng LH, Kohlhagen G, Liao ZY, Antony S, Sausville E, Pommier Y. Meng LH, et al. Cancer Res. 2005 Jun 15;65(12):5337-43. doi: 10.1158/0008-5472.CAN-05-0003. Cancer Res. 2005. PMID: 15958581
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275.
Kaur G, Stetler-Stevenson M, Sebers S, Worland P, Sedlacek H, Myers C, Czech J, Naik R, Sausville E. Kaur G, et al. J Natl Cancer Inst. 1992 Nov 18;84(22):1736-40. doi: 10.1093/jnci/84.22.1736. J Natl Cancer Inst. 1992. PMID: 1279187
Cytotoxicity and apoptosis of benzoquinones: redox cycling, cytochrome c release, and BAD protein expression.
Tudor G, Gutierrez P, Aguilera-Gutierrez A, Sausville EA. Tudor G, et al. Among authors: sausville ea. Biochem Pharmacol. 2003 Apr 1;65(7):1061-75. doi: 10.1016/s0006-2952(03)00013-3. Biochem Pharmacol. 2003. PMID: 12663042
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