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Bright future of optical assays for ion channel drug discovery.
Molokanova E, Savchenko A. Molokanova E, et al. Among authors: savchenko a. Drug Discov Today. 2008 Jan;13(1-2):14-22. doi: 10.1016/j.drudis.2007.11.009. Epub 2008 Jan 3. Drug Discov Today. 2008. PMID: 18190859 Review.
Ion channels are a key target class for drug discovery. The introduction of new and optimized optical probes, including fluorescent protein-based calcium sensors, luminescent photoproteins, voltage-sensitive probes and ion indicators, allows tackling a wide variety …
Ion channels are a key target class for drug discovery. The introduction of new and optimized optical probes, including fluorescent p …
Bringing new dimensions to drug discovery screening: impact of cellular stimulation technologies.
Molokanova E, Mercola M, Savchenko A. Molokanova E, et al. Among authors: savchenko a. Drug Discov Today. 2017 Jul;22(7):1045-1055. doi: 10.1016/j.drudis.2017.01.015. Epub 2017 Feb 4. Drug Discov Today. 2017. PMID: 28179145 Free PMC article. Review.
Assay technologies for screening ion channel targets.
Mattheakis LC, Savchenko A. Mattheakis LC, et al. Among authors: savchenko a. Curr Opin Drug Discov Devel. 2001 Jan;4(1):124-34. Curr Opin Drug Discov Devel. 2001. PMID: 11727318 Review.
To create a successful ion channel drug discovery program, it is necessary to quickly develop reliable and robust high-throughput screening (HTS) assays for those ion channels implicated in important diseases. ...
To create a successful ion channel drug discovery program, it is necessary to quickly develop reliable and robust high-throughput scr …
Graphene biointerfaces for optical stimulation of cells.
Savchenko A, Cherkas V, Liu C, Braun GB, Kleschevnikov A, Miller YI, Molokanova E. Savchenko A, et al. Sci Adv. 2018 May 18;4(5):eaat0351. doi: 10.1126/sciadv.aat0351. eCollection 2018 May. Sci Adv. 2018. PMID: 29795786 Free PMC article.
To address this need, we present a pioneering optical stimulation platform that does not require genetic modification of cells but instead capitalizes on unique optoelectronic properties of graphene, including its ability to efficiently convert light into electricity. ...
To address this need, we present a pioneering optical stimulation platform that does not require genetic modification of cells but in …
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M. McKeithan WL, et al. Among authors: savchenko a. Front Physiol. 2017 Oct 11;8:766. doi: 10.3389/fphys.2017.00766. eCollection 2017. Front Physiol. 2017. PMID: 29075196 Free PMC article.
However, a major roadblock to implementing hiPSC-CM technology in drug discovery is that conventional methods for monitoring action potential (AP) kinetics and arrhythmia phenotypes in vitro have been too costly or technically challenging to execute in high throughput. ... …
However, a major roadblock to implementing hiPSC-CM technology in drug discovery is that conventional methods for monitoring action p …
High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.
Cerignoli F, Charlot D, Whittaker R, Ingermanson R, Gehalot P, Savchenko A, Gallacher DJ, Towart R, Price JH, McDonough PM, Mercola M. Cerignoli F, et al. Among authors: savchenko a. J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):246-56. doi: 10.1016/j.vascn.2012.08.167. Epub 2012 Aug 25. J Pharmacol Toxicol Methods. 2012. PMID: 22926323 Free PMC article.
High throughput physiological screening of iPSC-derived cardiomyocytes for drug development.
Del Álamo JC, Lemons D, Serrano R, Savchenko A, Cerignoli F, Bodmer R, Mercola M. Del Álamo JC, et al. Among authors: savchenko a. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1717-27. doi: 10.1016/j.bbamcr.2016.03.003. Epub 2016 Mar 4. Biochim Biophys Acta. 2016. PMID: 26952934 Free PMC article. Review.
Human induced pluripotent stem cell derived cardiac tissue represents a potentially powerful means to model aspects of heart physiology relevant to disease and adverse drug effects, providing both the human context and throughput needed to improve the efficiency of drug de …
Human induced pluripotent stem cell derived cardiac tissue represents a potentially powerful means to model aspects of heart physiolo …
Nanostructured Antagonist of Extrasynaptic NMDA Receptors.
Savchenko A, Braun GB, Molokanova E. Savchenko A, et al. Nano Lett. 2016 Sep 14;16(9):5495-502. doi: 10.1021/acs.nanolett.6b01988. Epub 2016 Aug 9. Nano Lett. 2016. PMID: 27490923
Specifically, we designed a hybrid nanodrug (AuM) to be larger than the synaptic cleft by attaching memantine, NMDAR antagonist, via polymer linkers to a gold nanoparticle. ...Using a novel rational design strategy, we demonstrate a proof of concept fo …
Specifically, we designed a hybrid nanodrug (AuM) to be larger than the synaptic cleft by attaching memantine, NMDAR antagonist, via …
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart.
Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P. Wei K, et al. Among authors: savchenko a. Nature. 2015 Sep 24;525(7570):479-85. doi: 10.1038/nature15372. Epub 2015 Sep 16. Nature. 2015. PMID: 26375005 Free PMC article.
Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression. ...The data suggest that the loss of epicardial FSTL1 is …
Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 …
Epigenetic reprogramming of human embryonic stem cells into skeletal muscle cells and generation of contractile myospheres.
Albini S, Coutinho P, Malecova B, Giordani L, Savchenko A, Forcales SV, Puri PL. Albini S, et al. Among authors: savchenko a. Cell Rep. 2013 Mar 28;3(3):661-70. doi: 10.1016/j.celrep.2013.02.012. Epub 2013 Mar 7. Cell Rep. 2013. PMID: 23478022 Free PMC article.
Direct generation of a homogeneous population of skeletal myoblasts from human embryonic stem cells (hESCs) and formation of three-dimensional contractile structures for disease modeling in vitro are current challenges in regenerative medicine. ...These results identify BA …
Direct generation of a homogeneous population of skeletal myoblasts from human embryonic stem cells (hESCs) and formation of three-di …
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