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Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration.
Saxena S, Caroni P. Saxena S, et al. Neuron. 2011 Jul 14;71(1):35-48. doi: 10.1016/j.neuron.2011.06.031. Neuron. 2011. PMID: 21745636 Review.
Here, we discuss how a stressor-threshold model of how particular neurons and circuits are selectively vulnerable to disease may underly the etiology of familial and sporadic forms of diseases such as Alzheimer's, Parkinson's, Huntington's, and ALS. ...
Here, we discuss how a stressor-threshold model of how particular neurons and circuits are selectively vulnerable to disease may underly the …
Neurotrophins and neurodegenerative diseases: receptors stuck in traffic?
Kruttgen A, Saxena S, Evangelopoulos ME, Weis J. Kruttgen A, et al. J Neuropathol Exp Neurol. 2003 Apr;62(4):340-50. doi: 10.1093/jnen/62.4.340. J Neuropathol Exp Neurol. 2003. PMID: 12722826 Review.
Trophic factors in neurodegenerative disorders.
Weis J, Saxena S, Evangelopoulos ME, Kruttgen A. Weis J, et al. IUBMB Life. 2003 Jun;55(6):353-7. doi: 10.1080/1521654031000153021. IUBMB Life. 2003. PMID: 12938738 Review.
Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking.
Saxena S, Howe CL, Cosgaya JM, Steiner P, Hirling H, Chan JR, Weis J, Krüttgen A. Saxena S, et al. Mol Cell Neurosci. 2005 Mar;28(3):571-87. doi: 10.1016/j.mcn.2004.11.011. Mol Cell Neurosci. 2005. PMID: 15737746
Mechanisms of axon degeneration: from development to disease.
Saxena S, Caroni P. Saxena S, et al. Prog Neurobiol. 2007 Oct;83(3):174-91. doi: 10.1016/j.pneurobio.2007.07.007. Epub 2007 Aug 2. Prog Neurobiol. 2007. PMID: 17822833 Review.
Lesion-induced Wallerian degeneration is inhibited in the presence of Wld(S) fusion protein in neurons; it involves early local, and later, distal degeneration. ...
Lesion-induced Wallerian degeneration is inhibited in the presence of Wld(S) fusion protein in neurons; it involves early local, and …
Aberrant association of misfolded SOD1 with Na(+)/K(+)ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS.
Ruegsegger C, Maharjan N, Goswami A, Filézac de L'Etang A, Weis J, Troost D, Heller M, Gut H, Saxena S. Ruegsegger C, et al. Acta Neuropathol. 2016 Mar;131(3):427-51. doi: 10.1007/s00401-015-1510-4. Epub 2015 Nov 30. Acta Neuropathol. 2016. PMID: 26619836
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