Sayers JR - Search Results

1

A model for transition of 5'-nuclease domain of DNA polymerase I from inert to active modes.

Xie P, Sayers JR. Xie P, et al. Among authors: sayers jr. PLoS One. 2011 Jan 14;6(1):e16213. doi: 10.1371/journal.pone.0016213. PLoS One. 2011. PMID: 21264264 Free PMC article.

2

Active site substitutions delineate distinct classes of eubacterial flap endonuclease.

Allen LM, Hodskinson MR, Sayers JR. Allen LM, et al. Among authors: sayers jr. Biochem J. 2009 Mar 1;418(2):285-92. doi: 10.1042/BJ20081637. Biochem J. 2009. PMID: 19000038 Free PMC article.

3

Direct observation of DNA threading in flap endonuclease complexes.

AlMalki FA, Flemming CS, Zhang J, Feng M, Sedelnikova SE, Ceska T, Rafferty JB, Sayers JR, Artymiuk PJ. AlMalki FA, et al. Among authors: sayers jr. Nat Struct Mol Biol. 2016 Jul;23(7):640-6. doi: 10.1038/nsmb.3241. Epub 2016 Jun 6. Nat Struct Mol Biol. 2016. PMID: 27273516 Free PMC article.

4

The structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleases.

Anstey-Gilbert CS, Hemsworth GR, Flemming CS, Hodskinson MR, Zhang J, Sedelnikova SE, Stillman TJ, Sayers JR, Artymiuk PJ. Anstey-Gilbert CS, et al. Among authors: sayers jr. Nucleic Acids Res. 2013 Sep;41(17):8357-67. doi: 10.1093/nar/gkt591. Epub 2013 Jul 2. Nucleic Acids Res. 2013. PMID: 23821668 Free PMC article.

5

Molecular interactions of Escherichia coli ExoIX and identification of its associated 3'-5' exonuclease activity.

Hodskinson MR, Allen LM, Thomson DP, Sayers JR. Hodskinson MR, et al. Among authors: sayers jr. Nucleic Acids Res. 2007;35(12):4094-102. doi: 10.1093/nar/gkm396. Epub 2007 Jun 12. Nucleic Acids Res. 2007. PMID: 17567612 Free PMC article.

6

A conserved tyrosine residue aids ternary complex formation, but not catalysis, in phage T5 flap endonuclease.

Patel D, Tock MR, Frary E, Feng M, Pickering TJ, Grasby JA, Sayers JR. Patel D, et al. Among authors: sayers jr. J Mol Biol. 2002 Jul 26;320(5):1025-35. doi: 10.1016/s0022-2836(02)00547-8. J Mol Biol. 2002. PMID: 12126622

7

Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease.

Williams R, Sengerová B, Osborne S, Syson K, Ault S, Kilgour A, Chapados BR, Tainer JA, Sayers JR, Grasby JA. Williams R, et al. Among authors: sayers jr. J Mol Biol. 2007 Aug 3;371(1):34-48. doi: 10.1016/j.jmb.2007.04.063. Epub 2007 May 1. J Mol Biol. 2007. PMID: 17559871 Free PMC article.

8

Roles of divalent metal ions in flap endonuclease-substrate interactions.

Feng M, Patel D, Dervan JJ, Ceska T, Suck D, Haq I, Sayers JR. Feng M, et al. Among authors: sayers jr. Nat Struct Mol Biol. 2004 May;11(5):450-6. doi: 10.1038/nsmb754. Epub 2004 Apr 11. Nat Struct Mol Biol. 2004. PMID: 15077103

9

Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions.

Tomlinson CG, Syson K, Sengerová B, Atack JM, Sayers JR, Swanson L, Tainer JA, Williams NH, Grasby JA. Tomlinson CG, et al. Among authors: sayers jr. J Biol Chem. 2011 Sep 2;286(35):30878-30887. doi: 10.1074/jbc.M111.230391. Epub 2011 Jul 6. J Biol Chem. 2011. PMID: 21734257 Free PMC article.

10

Structure-specific DNA cleavage by 5' nucleases.

Ceska TA, Sayers JR. Ceska TA, et al. Among authors: sayers jr. Trends Biochem Sci. 1998 Sep;23(9):331-6. doi: 10.1016/s0968-0004(98)01259-6. Trends Biochem Sci. 1998. PMID: 9787638 Review.

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