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Page 1
Activation of membrane-associated procaspase-3 is regulated by Bcl-2.
Krebs JF, Armstrong RC, Srinivasan A, Aja T, Wong AM, Aboy A, Sayers R, Pham B, Vu T, Hoang K, Karanewsky DS, Leist C, Schmitz A, Wu JC, Tomaselli KJ, Fritz LC. Krebs JF, et al. J Cell Biol. 1999 Mar 8;144(5):915-26. doi: 10.1083/jcb.144.5.915. J Cell Biol. 1999. PMID: 10085291 Free PMC article.
Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications.
Ullman BR, Aja T, Deckwerth TL, Diaz JL, Herrmann J, Kalish VJ, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo SP, Sayers RO, Schmitz A, Ternansky RJ, Tomaselli KJ, Wu JC. Ullman BR, et al. Among authors: sayers ro. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3623-6. doi: 10.1016/s0960-894x(03)00755-8. Bioorg Med Chem Lett. 2003. PMID: 14505683
First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ. Linton SD, et al. Among authors: sayers ro. J Med Chem. 2005 Nov 3;48(22):6779-82. doi: 10.1021/jm050307e. J Med Chem. 2005. PMID: 16250635
Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads.
Ullman BR, Aja T, Chen N, Diaz JL, Gu X, Herrmann J, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs JJ, Linton SD, Meduna SP, Nalley K, Robinson ED, Roggo SP, Sayers RO, Schmitz A, Ternansky RJ, Tomaselli KJ, Wu JC. Ullman BR, et al. Among authors: sayers ro. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3632-6. doi: 10.1016/j.bmcl.2005.05.036. Bioorg Med Chem Lett. 2005. PMID: 15964758
Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Linton SD, Aja T, Allegrini PR, Deckwerth TL, Diaz JL, Hengerer B, Herrmann J, Jahangiri KG, Kallen J, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo S, Rovelli G, Sauter A, Sayers RO, Schmitz A, Smidt R, Ternansky RJ, Tomaselli KJ, Ullman BR, Wiessner C, Wu JC. Linton SD, et al. Among authors: sayers ro. Bioorg Med Chem Lett. 2004 May 17;14(10):2685-91. doi: 10.1016/j.bmcl.2003.12.106. Bioorg Med Chem Lett. 2004. PMID: 15109679
Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage.
Pandya P, Sayers RO, Ting JP, Morshedian S, Torres C, Cudal JS, Zhang K, Fitchett JR, Zhang Q, Zhang FF, Wang J, Durbin JD, Carrillo JJ, Espada A, Broughton H, Qian Y, Afshar S. Pandya P, et al. Among authors: sayers ro. PLoS One. 2020 Jun 1;15(6):e0233961. doi: 10.1371/journal.pone.0233961. eCollection 2020. PLoS One. 2020. PMID: 32479512 Free PMC article.