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Year Number of Results
2014 1
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23 results

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Page 1
RNA aggregates harness the danger response for potent cancer immunotherapy.
Mendez-Gomez HR, DeVries A, Castillo P, von Roemeling C, Qdaisat S, Stover BD, Xie C, Weidert F, Zhao C, Moor R, Liu R, Soni D, Ogando-Rivas E, Chardon-Robles J, McGuiness J, Zhang D, Chung MC, Marconi C, Michel S, Barpujari A, Jobin GW, Thomas N, Ma X, Campaneria Y, Grippin A, Karachi A, Li D, Sahay B, Elliott L, Foster TP, Coleman KE, Milner RJ, Sawyer WG, Ligon JA, Simon E, Cleaver B, Wynne K, Hodik M, Molinaro AM, Guan J, Kellish P, Doty A, Lee JH, Massini T, Kresak JL, Huang J, Hwang EI, Kline C, Carrera-Justiz S, Rahman M, Gatica S, Mueller S, Prados M, Ghiaseddin AP, Silver NL, Mitchell DA, Sayour EJ. Mendez-Gomez HR, et al. Among authors: sayour ej. Cell. 2024 May 9;187(10):2521-2535.e21. doi: 10.1016/j.cell.2024.04.003. Epub 2024 May 1. Cell. 2024. PMID: 38697107 Free PMC article.
In client-owned canines with terminal gliomas, RNA-LPAs improved survivorship and reprogrammed the TME, which became "hot" within days of a single infusion. ...These data support RNA-LPAs as a new technology that simultaneously reprograms the TME while eliciting rap …
In client-owned canines with terminal gliomas, RNA-LPAs improved survivorship and reprogrammed the TME, which became "hot" within day …
Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading.
Qdaisat S, Wummer B, Stover BD, Zhang D, McGuiness J, Weidert F, Chardon-Robles J, Grippin A, DeVries A, Zhao C, Marconi C, Karachi A, Xie C, Jobin G, Liu R, Michel S, Ma X, Moor RSF, von Roemeling C, Nguyen DT, Elliott L, Thomas N, Barpujari A, Geffrard H, Campaneria Y, Ogando-Rivas E, Rabideau C, Soni D, Huang J, Carrera-Justiz S, Fredenburg K, Silver NL, Sawyer WG, Rahman M, Ligon JA, Flores CT, Lee JH, Mitchell DA, Castillo P, Mendez-Gomez HR, Sayour EJ. Qdaisat S, et al. Among authors: sayour ej. Nat Biomed Eng. 2025 Sep;9(9):1437-1452. doi: 10.1038/s41551-025-01380-1. Epub 2025 Jul 18. Nat Biomed Eng. 2025. PMID: 40681861
Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in poorly immunogenic tumours and that these interferon responses can be enhanced via systemic administration of lipid particles loaded with …
Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in …
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade.
Grippin AJ, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong SD, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney MK, Schrank BR, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies AB, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan AA, Johns A; D3CODE Team; Lee J, Lee JH, Sun R, Sharma P, Tran H, Zhang J, Gibbons DL, Wargo J, Kim BYS, Heymach JV, Mendez-Gomez HR, Jiang W, Sayour EJ, Lin SH. Grippin AJ, et al. Among authors: sayour ej. Nature. 2025 Nov;647(8089):488-497. doi: 10.1038/s41586-025-09655-y. Epub 2025 Oct 22. Nature. 2025. PMID: 41125896 Free PMC article.
Contemporary RNA Therapeutics for Glioblastoma.
Melnick K, Dastmalchi F, Mitchell D, Rahman M, Sayour EJ. Melnick K, et al. Among authors: sayour ej. Neuromolecular Med. 2022 Mar;24(1):8-12. doi: 10.1007/s12017-021-08669-9. Epub 2021 Jun 8. Neuromolecular Med. 2022. PMID: 34101090 Free PMC article. Review.
RNA offers clear advantages over antigen-focused approaches but cannot often be directly administered due to biological instability. This review will focus on utilization of RNA dendritic cell vaccines and RNA nanoparticle therapies in the treatment of GBM. …
RNA offers clear advantages over antigen-focused approaches but cannot often be directly administered due to biological instability. …
Therapeutic mRNA vaccine applications in oncology.
Elliott L, Foster T, Castillo P, Mendez-Gomez H, Sayour EJ. Elliott L, et al. Among authors: sayour ej. Mol Ther. 2025 Jun 4;33(6):2610-2618. doi: 10.1016/j.ymthe.2025.04.044. Epub 2025 May 6. Mol Ther. 2025. PMID: 40336197 Free PMC article. Review.
Lipid particle delivery vehicles can protect RNA from degradation and promote delivery to intended targets in vivo. In this mini-review, we discuss mRNA vaccine mechanisms and capacity for enhancement followed by progress to date in the clinical development of mRNA cancer …
Lipid particle delivery vehicles can protect RNA from degradation and promote delivery to intended targets in vivo. In this mini-revi …
Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes.
Sayour EJ, Mendez-Gomez HR, Mitchell DA. Sayour EJ, et al. Int J Mol Sci. 2018 Sep 23;19(10):2890. doi: 10.3390/ijms19102890. Int J Mol Sci. 2018. PMID: 30249040 Free PMC article. Review.
Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this review, we discuss liposomes as RNA delivery vehicles and their role as cancer vaccines....
Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this …
Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors.
Carrera-Justiz S, Aghaee M, Qdaisat S, Weidert F, Garcia GA, Fagman L, Zhang D, Stover B, Moor RSF, Xie C, Goldenberg E, von Roemeling C, Doonan B, Chardon-Robles J, Elliott L, Sawyer WG, Deleyrolle LP, Sahay B, Foster TP, Seligson ND, Rahman M, Ghiaseddin A, Castillo P, Lee JH, Silver NL, Doty A, Ligon JA, Milner RJ, Mitchell D, Mendez-Gomez H, Moore H, Sayour EJ. Carrera-Justiz S, et al. Among authors: sayour ej. J Immunother Cancer. 2025 Nov 11;13(11):e011817. doi: 10.1136/jitc-2025-011817. J Immunother Cancer. 2025. PMID: 41218853 Free PMC article.
Spontaneously arising canine glioma exhibits important molecular and pathological similarities to malignant pediatric glioma, making it an invaluable model for testing novel therapies. We evaluated safety and activity of RNA lipid particle aggregates (LPAs) designed to pro …
Spontaneously arising canine glioma exhibits important molecular and pathological similarities to malignant pediatric glioma, making it an i …
Catching a chameleon.
Sayour EJ. Sayour EJ. Science. 2026 Apr 2;392(6793):45. doi: 10.1126/science.aef9970. Epub 2026 Apr 2. Science. 2026. PMID: 41926582
Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity.
Mendez-Gomez HR, Ligon JA, Ghiaseddin AP, Sayour EJ. Mendez-Gomez HR, et al. Among authors: sayour ej. Hum Vaccin Immunother. 2025 Dec;21(1):2543599. doi: 10.1080/21645515.2025.2543599. Epub 2025 Aug 19. Hum Vaccin Immunother. 2025. PMID: 40827907 Free PMC article.
In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the ability to reprogram both the tumor microenvironment and periphery enabling cancer-specific immunity simultaneously generated to compete agains …
In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the abi …
23 results