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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.
Maneix L, Iakova P, Lee CG, Moree SE, Lu X, Datar GK, Hill CT, Spooner E, King JCK, Sykes DB, Saez B, Di Stefano B, Chen X, Krause DS, Sahin E, Tsai FTF, Goodell MA, Berk BC, Scadden DT, Catic A. Maneix L, et al. Among authors: scadden dt. Nat Cell Biol. 2024 Apr;26(4):593-603. doi: 10.1038/s41556-024-01387-x. Epub 2024 Mar 29. Nat Cell Biol. 2024. PMID: 38553595 Free PMC article.
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.
Bonora M, Morganti C, van Gastel N, Ito K, Calura E, Zanolla I, Ferroni L, Zhang Y, Jung Y, Sales G, Martini P, Nakamura T, Lasorsa FM, Finkel T, Lin CP, Zavan B, Pinton P, Georgakoudi I, Romualdi C, Scadden DT, Ito K. Bonora M, et al. Among authors: scadden dt. Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10. doi: 10.1016/j.stem.2024.02.004. Cell Stem Cell. 2024. PMID: 38458178 Free article.
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice.
Saha A, Palchaudhuri R, Lanieri L, Hyzy S, Riddle MJ, Panthera J, Eide C, Tolar J, Panoskaltsis-Mortari A, Gorfinkel L, Tkachev V, Gerdemann U, Alvarez-Calderon F, Palato ER, MacMillan ML, Wagner JE, Kean LS, Osborn M, Kiem HP, Scadden DT, Olson LM, Blazar BR. Saha A, et al. Among authors: scadden dt. Blood. 2024 Mar 6:blood.2023023549. doi: 10.1182/blood.2023023549. Online ahead of print. Blood. 2024. PMID: 38447038
Stromal Cell Isolation from Hematopoietic Organs.
Kristiansen T, Mayerhofer C, Gustafsson K, Scadden DT. Kristiansen T, et al. Among authors: scadden dt. J Vis Exp. 2024 Jan 26;(203). doi: 10.3791/66231. J Vis Exp. 2024. PMID: 38345255
Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions.
Mei S, Alchahin AM, Tsea I, Kfoury Y, Hirz T, Jeffries NE, Zhao T, Xu Y, Zhang H, Sarkar H, Wu S, Subtelny AO, Johnsen JI, Zhang Y, Salari K, Wu CL, Randolph MA, Scadden DT, Dahl DM, Shin J, Kharchenko PV, Saylor PJ, Sykes DB, Baryawno N. Mei S, et al. Among authors: scadden dt. Genome Med. 2024 Jan 29;16(1):1. doi: 10.1186/s13073-023-01272-6. Genome Med. 2024. PMID: 38281962 Free PMC article.
Health Consequences of Thymus Removal in Adults. Reply.
Kooshesh KA, Gustafsson K, Scadden DT. Kooshesh KA, et al. Among authors: scadden dt. N Engl J Med. 2023 Nov 2;389(18):1726-1727. doi: 10.1056/NEJMc2310640. N Engl J Med. 2023. PMID: 37913517 No abstract available.
Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo.
Massengale M, Massengale JL, Benson CR, Baryawno N, Oki T, Steinhauser ML, Wang A, Balani D, Oh LS, Randolph MA, Gill TJ 3rd, Kronenberg HM, Scadden DT. Massengale M, et al. Among authors: scadden dt. JCI Insight. 2023 Sep 8;8(17):e167858. doi: 10.1172/jci.insight.167858. JCI Insight. 2023. PMID: 37681409 Free PMC article.
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Miller PG, Sperling AS, Mayerhofer C, McConkey ME, Ellegast JM, Da Silva C, Cohen DN, Wang C, Sharda A, Yan N, Saha S, Schluter C, Schechter I, Słabicki M, Sandoval B, Kahn J, Boettcher S, Gibson CJ, Scadden DT, Stegmaier K, Bhatt S, Lindsley RC, Ebert BL. Miller PG, et al. Among authors: scadden dt. Blood. 2023 Dec 14;142(24):2079-2091. doi: 10.1182/blood.2023020331. Blood. 2023. PMID: 37595362 Free PMC article.
380 results