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Polyphenols and prevention of cardiovascular diseases.
Manach C, Mazur A, Scalbert A. Manach C, et al. Curr Opin Lipidol. 2005 Feb;16(1):77-84. doi: 10.1097/00041433-200502000-00013. Curr Opin Lipidol. 2005. PMID: 15650567 Review.
RECENT FINDINGS: A large number of recent intervention studies have shown that several biomarkers of cardiovascular risk are influenced by the consumption of polyphenol-rich foods. ...All clinical studies have used foods or beverages containing a mixture of differen …
RECENT FINDINGS: A large number of recent intervention studies have shown that several biomarkers of cardiovascular risk are influenc …
Isotopic labelling of dietary polyphenols for bioavailability studies.
Déprez S, Scalbert A. Déprez S, et al. Basic Life Sci. 1999;66:357-70. doi: 10.1007/978-1-4615-4139-4_19. Basic Life Sci. 1999. PMID: 10800453 Review. No abstract available.
Polyphenols, metal ion complexation and biological consequences.
Scalbert A, Mila I, Expert D, Marmolle F, Albrecht AM, Hurrell R, Huneau JF, Tomé D. Scalbert A, et al. Basic Life Sci. 1999;66:545-54. doi: 10.1007/978-1-4615-4139-4_30. Basic Life Sci. 1999. PMID: 10800462 Review. No abstract available.
Dietary intake and bioavailability of polyphenols.
Scalbert A, Williamson G. Scalbert A, et al. J Nutr. 2000 Aug;130(8S Suppl):2073S-85S. doi: 10.1093/jn/130.8.2073S. J Nutr. 2000. PMID: 10917926 Review.
The main dietary sources of polyphenols are reviewed, and the daily intake is calculated for a given diet containing some common fruits, vegetables and beverages. ...The maximum concentration in plasma rarely exceeds 1 microM after the consumption of 10-100 mg of a
The main dietary sources of polyphenols are reviewed, and the daily intake is calculated for a given diet containing some common frui …
Proanthocyanidins and human health: systemic effects and local effects in the gut.
Scalbert A, Déprez S, Mila I, Albrecht AM, Huneau JF, Rabot S. Scalbert A, et al. Biofactors. 2000;13(1-4):115-20. doi: 10.1002/biof.5520130119. Biofactors. 2000. PMID: 11237169 Review.
They have a high affinity for proteins and their absorption through the gut barrier is likely limited to the molecules of low polymerization degree and to the metabolites formed by the colonic microflora, as suggested by in vitro experiments. ...
They have a high affinity for proteins and their absorption through the gut barrier is likely limited to the molecules of low polymer …
Catechin is metabolized by both the small intestine and liver of rats.
Donovan JL, Crespy V, Manach C, Morand C, Besson C, Scalbert A, Rémésy C. Donovan JL, et al. J Nutr. 2001 Jun;131(6):1753-7. doi: 10.1093/jn/131.6.1753. J Nutr. 2001. PMID: 11385063
Effluent samples contained only native catechin, indicating that intestinal excretion of metabolites is not a mechanism of catechin elimination. ...
Effluent samples contained only native catechin, indicating that intestinal excretion of metabolites is not a mechanism of catechin e …
Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3.
Donovan JL, Manach C, Rios L, Morand C, Scalbert A, Rémésy C. Donovan JL, et al. Br J Nutr. 2002 Apr;87(4):299-306. doi: 10.1079/bjnbjn2001517. Br J Nutr. 2002. PMID: 12064339
In the present study, catechin, the procyanidin dimer B3 and a grape-seed extract containing catechin, epicatechin and a mixture of procyanidins were fed to rats in a single meal. ...
In the present study, catechin, the procyanidin dimer B3 and a grape-seed extract containing catechin, epicatechin and a mixtu …
Absorption and metabolism of polyphenols in the gut and impact on health.
Scalbert A, Morand C, Manach C, Rémésy C. Scalbert A, et al. Biomed Pharmacother. 2002 Aug;56(6):276-82. doi: 10.1016/s0753-3322(02)00205-6. Biomed Pharmacother. 2002. PMID: 12224598 Review.
They show a considerable structural diversity, which largely influences their bioavailability. Phenolic acids like caffeic acid are easily absorbed through the gut barrier, whereas large molecular weight polyphenols such as proanthocyanidins are very poorly absorbed. ...Th …
They show a considerable structural diversity, which largely influences their bioavailability. Phenolic acids like caffeic acid are e …
Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols.
Gonthier MP, Cheynier V, Donovan JL, Manach C, Morand C, Mila I, Lapierre C, Rémésy C, Scalbert A. Gonthier MP, et al. J Nutr. 2003 Feb;133(2):461-7. doi: 10.1093/jn/133.2.461. J Nutr. 2003. PMID: 12566484
We measured the microbial metabolites formed in four groups of rats (n = 8) fed for 8 d a diet supplemented with 0.12 g/100 g catechin, 0.25 or 0.50 g/100 g red wine powder containing proanthocyanidins, phenolic acids, flavanols, anthocyanins and flavonols or an unsuppleme …
We measured the microbial metabolites formed in four groups of rats (n = 8) fed for 8 d a diet supplemented with 0.12 g/100 g catechi …
Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects.
Rios LY, Gonthier MP, Rémésy C, Mila I, Lapierre C, Lazarus SA, Williamson G, Scalbert A. Rios LY, et al. Am J Clin Nutr. 2003 Apr;77(4):912-8. doi: 10.1093/ajcn/77.4.912. Am J Clin Nutr. 2003. PMID: 12663291
DESIGN: After consumption of a polyphenol-free diet for 2 d and a subsequent overnight fast, 11 healthy subjects (7 men and 4 women) consumed 80 g chocolate containing 439 mg proanthocyanidins and 147 mg catechin monomers. ...
DESIGN: After consumption of a polyphenol-free diet for 2 d and a subsequent overnight fast, 11 healthy subjects (7 men and 4 …
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