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Epidemiological surveillance of leishmaniasis in HIV-1-infected individuals in Italy.
Gradoni L, Scalone A, Gramiccia M, Troiani M. Gradoni L, et al. AIDS. 1996 Jun;10(7):785-91. doi: 10.1097/00002030-199606001-00014. AIDS. 1996. PMID: 8805871
Leishmania incidence estimated among approximately 2700 AIDS patients living in leishmaniasis endemic areas averaged 1.6%, with a maximum of 4.9% in Sicily. ...The isoenzyme characterization of 38 Leishmania stocks showed a zymodeme spectrum qualitatively and quanti …
Leishmania incidence estimated among approximately 2700 AIDS patients living in leishmaniasis endemic areas averaged 1.6%, with a max …
Canine Antibodies against Salivary Recombinant Proteins of Phlebotomus perniciosus: A Longitudinal Study in an Endemic Focus of Canine Leishmaniasis.
Kostalova T, Lestinova T, Sumova P, Vlkova M, Rohousova I, Berriatua E, Oliva G, Fiorentino E, Scalone A, Gramiccia M, Gradoni L, Volf P. Kostalova T, et al. PLoS Negl Trop Dis. 2015 Jun 25;9(6):e0003855. doi: 10.1371/journal.pntd.0003855. eCollection 2015. PLoS Negl Trop Dis. 2015. PMID: 26111018 Free PMC article.
We found a significant association between active CanL infection and the amount of anti-P. perniciosus saliva antibodies. Importantly, we detected a high correlation between IgG antibodies recognizing rSP03B protein and the whole salivary antigen. The kinetics of an …
We found a significant association between active CanL infection and the amount of anti-P. perniciosus saliva antibodies. Importantly …
A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons.
Oliva G, Nieto J, Foglia Manzillo V, Cappiello S, Fiorentino E, Di Muccio T, Scalone A, Moreno J, Chicharro C, Carrillo E, Butaud T, Guegand L, Martin V, Cuisinier AM, McGahie D, Gueguen S, Cañavate C, Gradoni L. Oliva G, et al. PLoS Negl Trop Dis. 2014 Oct 9;8(10):e3213. doi: 10.1371/journal.pntd.0003213. eCollection 2014 Oct. PLoS Negl Trop Dis. 2014. PMID: 25299614 Free PMC article. Clinical Trial.
The vaccine was well-tolerated, and provided a significant reduction in the risk of progressing to uncontrolled active infection (p = 0.025) or symptomatic disease (p = 0.046), with an efficacy of 68.4% and a protection rate of 92.7%. ...In conclusion, we confirmed …
The vaccine was well-tolerated, and provided a significant reduction in the risk of progressing to uncontrolled active infection (p = …
Prospective study on the incidence and progression of clinical signs in naïve dogs naturally infected by Leishmania infantum.
Foglia Manzillo V, Di Muccio T, Cappiello S, Scalone A, Paparcone R, Fiorentino E, Gizzarelli M, Gramiccia M, Gradoni L, Oliva G. Foglia Manzillo V, et al. PLoS Negl Trop Dis. 2013 May 9;7(5):e2225. doi: 10.1371/journal.pntd.0002225. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23675551 Free PMC article.
At M22 the prevalence of any Leishmania infection stage classified as subpatent, active asymptomatic, or symptomatic was 59.8% in studies A-C and 29.2% in study D. ...Most clinicopathological alterations became evident from M12, although a few cases of thrombocytope …
At M22 the prevalence of any Leishmania infection stage classified as subpatent, active asymptomatic, or symptomatic was 59.8% in studies …
First record of autochthonous canine leishmaniasis in Hungary.
Tánczos B, Balogh N, Király L, Biksi I, Szeredi L, Gyurkovsky M, Scalone A, Fiorentino E, Gramiccia M, Farkas R. Tánczos B, et al. Vector Borne Zoonotic Dis. 2012 Jul;12(7):588-94. doi: 10.1089/vbz.2011.0906. Epub 2012 May 18. Vector Borne Zoonotic Dis. 2012. PMID: 22607079 Free PMC article.
Hungary is traditionally regarded as a leishmaniasis-free country, and human or canine cases diagnosed locally have been recorded as imported. ...Following the occurrence in October 2007 of an undisputable clinical case of L. infantum canine leishmaniasis (CanL) in a
Hungary is traditionally regarded as a leishmaniasis-free country, and human or canine cases diagnosed locally have been recorded as …
Risk assessment for canine leishmaniasis spreading in the north of Italy.
Morosetti G, Bongiorno G, Beran B, Scalone A, Moser J, Gramiccia M, Gradoni L, Maroli M. Morosetti G, et al. Geospat Health. 2009 Nov;4(1):115-27. doi: 10.4081/gh.2009.214. Geospat Health. 2009. PMID: 19908194
Leishmania serology on local dogs kept in kennels gave negative results, while only imported canine leishmaniasis cases were reported by local veterinaries through a questionnaire survey. ...
Leishmania serology on local dogs kept in kennels gave negative results, while only imported canine leishmaniasis cases were reported by loc …
Incidence and time course of Leishmania infantum infections examined by parasitological, serologic, and nested-PCR techniques in a cohort of naive dogs exposed to three consecutive transmission seasons.
Oliva G, Scalone A, Foglia Manzillo V, Gramiccia M, Pagano A, Di Muccio T, Gradoni L. Oliva G, et al. J Clin Microbiol. 2006 Apr;44(4):1318-22. doi: 10.1128/JCM.44.4.1318-1322.2006. J Clin Microbiol. 2006. PMID: 16597857 Free PMC article.
A longitudinal study was performed on 43 beagle dogs exposed to three transmission seasons (2002 to 2004) of Mediterranean leishmaniasis and examined periodically over 32 months through bone marrow microscopy and nested PCR (n-PCR), lymph node culture, serology (immunofluo
A longitudinal study was performed on 43 beagle dogs exposed to three transmission seasons (2002 to 2004) of Mediterranean leishmania
Longitudinal study on the detection of canine Leishmania infections by conjunctival swab analysis and correlation with entomological parameters.
Gramiccia M, Di Muccio T, Fiorentino E, Scalone A, Bongiorno G, Cappiello S, Paparcone R, Foglia Manzillo V, Maroli M, Gradoni L, Oliva G. Gramiccia M, et al. Vet Parasitol. 2010 Aug 4;171(3-4):223-8. doi: 10.1016/j.vetpar.2010.03.025. Epub 2010 Mar 20. Vet Parasitol. 2010. PMID: 20409639
(A) Sixty-five IFAT- and CS n-PCR-negative dogs exposed to, and followed up once or twice a month during a full sand fly season (July-November 2008). In parallel, a sand fly survey was performed on site using standard sticky traps set twice a mo …
(A) Sixty-five IFAT- and CS n-PCR-negative dogs exposed to, and followed up once or twice a month during a full sand fl …
Serological and molecular tools to diagnose visceral leishmaniasis: 2-years' experience of a single center in Northern Italy.
Varani S, Ortalli M, Attard L, Vanino E, Gaibani P, Vocale C, Rossini G, Cagarelli R, Pierro A, Billi P, Mastroianni A, Di Cesare S, Codeluppi M, Franceschini E, Melchionda F, Gramiccia M, Scalone A, Gentilomi GA, Landini MP. Varani S, et al. Among authors: scalone a. PLoS One. 2017 Aug 23;12(8):e0183699. doi: 10.1371/journal.pone.0183699. eCollection 2017. PLoS One. 2017. PMID: 28832646 Free PMC article.
Epidemiology of Imported Leishmaniasis in Italy: Implications for a European Endemic Country.
Di Muccio T, Scalone A, Bruno A, Marangi M, Grande R, Armignacco O, Gradoni L, Gramiccia M. Di Muccio T, et al. PLoS One. 2015 Jun 26;10(6):e0129418. doi: 10.1371/journal.pone.0129418. eCollection 2015. PLoS One. 2015. PMID: 26114938 Free PMC article.
A total of 105 imported cases were recorded (annual range: 0-20) of which 36 were visceral (VL) (16 HIV-coinfections) and 69 cutaneous (CL) cases; 85 cases (52 CL) were from the Old World and 20 (17 CL) from the New World. ...In contrast, a steady increase of CL cas
A total of 105 imported cases were recorded (annual range: 0-20) of which 36 were visceral (VL) (16 HIV-coinfections) and 69 cutaneou
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