Scapin G - Search Results

1

Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.

Scapin G, Patel SB, Chung C, Varnerin JP, Edmondson SD, Mastracchio A, Parmee ER, Singh SB, Becker JW, Van der Ploeg LH, Tota MR. Scapin G, et al. Biochemistry. 2004 May 25;43(20):6091-100. doi: 10.1021/bi049868i. Biochemistry. 2004. PMID: 15147193

2

The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.

Scapin G, Patel SB, Becker JW, Wang Q, Desponts C, Waddleton D, Skorey K, Cromlish W, Bayly C, Therien M, Gauthier JY, Li CS, Lau CK, Ramachandran C, Kennedy BP, Asante-Appiah E. Scapin G, et al. Biochemistry. 2003 Oct 7;42(39):11451-9. doi: 10.1021/bi035098j. Biochemistry. 2003. PMID: 14516196

3

Crystallization and preliminary X-ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B.

Patel SB, Varnerin JP, Tota MR, Edmondson SD, Parmee ER, Becker JW, Scapin G. Patel SB, et al. Among authors: scapin g. Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):169-71. doi: 10.1107/s0907444903025101. Epub 2003 Dec 18. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 14684919

4

Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core.

Varnerin JP, Chung CC, Patel SB, Scapin G, Parmee ER, Morin NR, MacNeil DJ, Cully DF, Van der Ploeg LH, Tota MR. Varnerin JP, et al. Among authors: scapin g. Protein Expr Purif. 2004 Jun;35(2):225-36. doi: 10.1016/j.pep.2004.01.009. Protein Expr Purif. 2004. PMID: 15135397

5

The role of tryptophan 1072 in human PDE3B inhibitor binding.

Chung C, Varnerin JP, Morin NR, MacNeil DJ, Singh SB, Patel S, Scapin G, Van der Ploeg LH, Tota MR. Chung C, et al. Among authors: scapin g. Biochem Biophys Res Commun. 2003 Aug 8;307(4):1045-50. doi: 10.1016/s0006-291x(03)01299-3. Biochem Biophys Res Commun. 2003. PMID: 12878217

6

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.

Scapin G, Patel SB, Lisnock J, Becker JW, LoGrasso PV. Scapin G, et al. Chem Biol. 2003 Aug;10(8):705-12. doi: 10.1016/s1074-5521(03)00159-5. Chem Biol. 2003. PMID: 12954329

7

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.

Asante-Appiah E, Patel S, Dufresne C, Roy P, Wang Q, Patel V, Friesen RW, Ramachandran C, Becker JW, Leblanc Y, Kennedy BP, Scapin G. Asante-Appiah E, et al. Among authors: scapin g. Biochemistry. 2002 Jul 23;41(29):9043-51. doi: 10.1021/bi0259554. Biochemistry. 2002. PMID: 12119018

8

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.

Fitzgerald CE, Patel SB, Becker JW, Cameron PM, Zaller D, Pikounis VB, O'Keefe SJ, Scapin G. Fitzgerald CE, et al. Among authors: scapin g. Nat Struct Biol. 2003 Sep;10(9):764-9. doi: 10.1038/nsb949. Epub 2003 Aug 3. Nat Struct Biol. 2003. PMID: 12897767

9

Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.

Patel SB, Cameron PM, Frantz-Wattley B, O'Neill E, Becker JW, Scapin G. Patel SB, et al. Among authors: scapin g. Biochim Biophys Acta. 2004 Jan 14;1696(1):67-73. doi: 10.1016/j.bbapap.2003.09.009. Biochim Biophys Acta. 2004. PMID: 14726206

10

Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.

Asante-Appiah E, Patel S, Desponts C, Taylor JM, Lau C, Dufresne C, Therien M, Friesen R, Becker JW, Leblanc Y, Kennedy BP, Scapin G. Asante-Appiah E, et al. Among authors: scapin g. J Biol Chem. 2006 Mar 24;281(12):8010-5. doi: 10.1074/jbc.M511827200. Epub 2006 Jan 6. J Biol Chem. 2006. PMID: 16407290 Free article.

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