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NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.
Jaquet V, Marcoux J, Forest E, Leidal KG, McCormick S, Westermaier Y, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Fieschi F, Krause KH, Bedard K. Jaquet V, et al. Among authors: scapozza l. Br J Pharmacol. 2011 Sep;164(2b):507-20. doi: 10.1111/j.1476-5381.2011.01439.x. Br J Pharmacol. 2011. PMID: 21501142 Free PMC article.
A subset of N-substituted phenothiazines inhibits NADPH oxidases.
Seredenina T, Chiriano G, Filippova A, Nayernia Z, Mahiout Z, Fioraso-Cartier L, Plastre O, Scapozza L, Krause KH, Jaquet V. Seredenina T, et al. Among authors: scapozza l. Free Radic Biol Med. 2015 Sep;86:239-49. doi: 10.1016/j.freeradbiomed.2015.05.023. Epub 2015 May 23. Free Radic Biol Med. 2015. PMID: 26013584
RET kinase inhibitors: a review of recent patents (2012-2015).
Mologni L, Gambacorti-Passerini C, Goekjian P, Scapozza L. Mologni L, et al. Among authors: scapozza l. Expert Opin Ther Pat. 2017 Jan;27(1):91-99. doi: 10.1080/13543776.2017.1238073. Epub 2016 Sep 26. Expert Opin Ther Pat. 2017. PMID: 27646564 Review.
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