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PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.
Salvati E, Scarsella M, Porru M, Rizzo A, Iachettini S, Tentori L, Graziani G, D'Incalci M, Stevens MF, Orlandi A, Passeri D, Gilson E, Zupi G, Leonetti C, Biroccio A. Salvati E, et al. Oncogene. 2010 Nov 25;29(47):6280-93. doi: 10.1038/onc.2010.344. Epub 2010 Aug 30. Oncogene. 2010. PMID: 20802516
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.
Tentori L, Muzi A, Dorio AS, Scarsella M, Leonetti C, Shah GM, Xu W, Camaioni E, Gold B, Pellicciari R, Dantzer F, Zhang J, Graziani G. Tentori L, et al. Curr Cancer Drug Targets. 2010 Jun;10(4):368-83. doi: 10.2174/156800910791208571. Curr Cancer Drug Targets. 2010. PMID: 20464779
Silencing of PARP-1 in melanoma or cervical carcinoma lines enhanced in vitro sensitivity to TMZ and Me- Lex, and induced a higher level of cell accumulation at the G2/M phase of cell cycle with respect to controls. ...However, it induced different cell cycle modulations d …
Silencing of PARP-1 in melanoma or cervical carcinoma lines enhanced in vitro sensitivity to TMZ and Me- Lex, and induced a higher level of …
Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.
Del Bufalo D, Trisciuoglio D, Biroccio A, Marcocci L, Buglioni S, Candiloro A, Scarsella M, Leonetti C, Zupi G. Del Bufalo D, et al. J Cell Biochem. 2001 Aug 21-Sep 5;83(3):473-83. doi: 10.1002/jcb.1245. J Cell Biochem. 2001. PMID: 11596115
Cell cycle analysis demonstrated that while BCNU induced a consistent block in S/G2-M phases of the cell cycle in the control clone, it did not affect the cell cycle phase distribution of the two bcl-2 transfectants. ...
Cell cycle analysis demonstrated that while BCNU induced a consistent block in S/G2-M phases of the cell cycle in the control clone, …
Che-1 activates XIAP expression in response to DNA damage.
Bruno T, Iezzi S, De Nicola F, Di Padova M, Desantis A, Scarsella M, Di Certo MG, Leonetti C, Floridi A, Passananti C, Fanciulli M. Bruno T, et al. Cell Death Differ. 2008 Mar;15(3):515-20. doi: 10.1038/sj.cdd.4402284. Epub 2007 Nov 30. Cell Death Differ. 2008. PMID: 18049476
Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis.
Tentori L, Lacal PM, Muzi A, Dorio AS, Leonetti C, Scarsella M, Ruffini F, Xu W, Min W, Stoppacciaro A, Colarossi C, Wang ZQ, Zhang J, Graziani G. Tentori L, et al. Eur J Cancer. 2007 Sep;43(14):2124-33. doi: 10.1016/j.ejca.2007.07.010. Epub 2007 Aug 21. Eur J Cancer. 2007. PMID: 17714938
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
Tentori L, Leonetti C, Scarsella M, D'Amati G, Vergati M, Portarena I, Xu W, Kalish V, Zupi G, Zhang J, Graziani G. Tentori L, et al. Clin Cancer Res. 2003 Nov 1;9(14):5370-9. Clin Cancer Res. 2003. PMID: 14614022
Alpha-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy.
Leonetti C, Biroccio A, Gabellini C, Scarsella M, Maresca V, Flori E, Bove L, Pace A, Stoppacciaro A, Zupi G, Cognetti F, Picardo M. Leonetti C, et al. Int J Cancer. 2003 Mar 20;104(2):243-50. doi: 10.1002/ijc.10933. Int J Cancer. 2003. PMID: 12569582
Efficacy of a nitric oxide-releasing nonsteroidal anti-inflammatory drug and cytotoxic drugs in human colon cancer cell lines in vitro and xenografts.
Leonetti C, Scarsella M, Zupi G, Zoli W, Amadori D, Medri L, Fabbri F, Rosetti M, Ulivi P, Cecconetto L, Bolla M, Tesei A. Leonetti C, et al. Mol Cancer Ther. 2006 Apr;5(4):919-26. doi: 10.1158/1535-7163.MCT-05-0536. Mol Cancer Ther. 2006. PMID: 16648562
Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft.
Spugnini EP, Biroccio A, De Mori R, Scarsella M, D'Angelo C, Baldi A, Leonetti C. Spugnini EP, et al. J Transl Med. 2011 Jul 28;9:125. doi: 10.1186/1479-5876-9-125. J Transl Med. 2011. PMID: 21798045 Free PMC article.
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