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Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.
Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS. Schietke RE, et al. Among authors: schodel j. PLoS One. 2012;7(1):e31034. doi: 10.1371/journal.pone.0031034. Epub 2012 Jan 27. PLoS One. 2012. PMID: 22299048 Free PMC article.
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model.
Bernhardt WM, Gottmann U, Doyon F, Buchholz B, Campean V, Schödel J, Reisenbuechler A, Klaus S, Arend M, Flippin L, Willam C, Wiesener MS, Yard B, Warnecke C, Eckardt KU. Bernhardt WM, et al. Among authors: schodel j. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21276-81. doi: 10.1073/pnas.0903978106. Epub 2009 Nov 23. Proc Natl Acad Sci U S A. 2009. PMID: 19934037 Free PMC article.
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.
Schietke R, Warnecke C, Wacker I, Schödel J, Mole DR, Campean V, Amann K, Goppelt-Struebe M, Behrens J, Eckardt KU, Wiesener MS. Schietke R, et al. Among authors: schodel j. J Biol Chem. 2010 Feb 26;285(9):6658-69. doi: 10.1074/jbc.M109.042424. Epub 2009 Dec 21. J Biol Chem. 2010. PMID: 20026874 Free PMC article.
Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C. Jantsch J, et al. Among authors: schodel j. J Leukoc Biol. 2011 Sep;90(3):551-62. doi: 10.1189/jlb.1210683. Epub 2011 Jun 17. J Leukoc Biol. 2011. PMID: 21685248
56 results