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The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells.
Chen TC, Wadsten P, Su S, Rawlinson N, Hofman FM, Hill CK, Schönthal AH. Chen TC, et al. Among authors: schonthal ah. Cancer Biol Ther. 2002 May-Jun;1(3):268-76. doi: 10.4161/cbt.80. Cancer Biol Ther. 2002. PMID: 12432276
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