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Stimulation of free radical formation by aminoglycoside antibiotics.
Sha SH, Schacht J. Sha SH, et al. Among authors: schacht j. Hear Res. 1999 Feb;128(1-2):112-8. doi: 10.1016/s0378-5955(98)00200-7. Hear Res. 1999. PMID: 10082291
New developments in aminoglycoside therapy and ototoxicity.
Xie J, Talaska AE, Schacht J. Xie J, et al. Among authors: schacht j. Hear Res. 2011 Nov;281(1-2):28-37. doi: 10.1016/j.heares.2011.05.008. Epub 2011 May 27. Hear Res. 2011. PMID: 21640178 Free PMC article. Review.
Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.
Shalev M, Rozenberg H, Smolkin B, Nasereddin A, Kopelyanskiy D, Belakhov V, Schrepfer T, Schacht J, Jaffe CL, Adir N, Baasov T. Shalev M, et al. Among authors: schacht j. Nucleic Acids Res. 2015 Sep 30;43(17):8601-13. doi: 10.1093/nar/gkv821. Epub 2015 Aug 11. Nucleic Acids Res. 2015. PMID: 26264664 Free PMC article.
Inhibition of renal ornithine decarboxylase by aminoglycoside antibiotics in vitro.
Henley CM 3rd, Mahran LG, Schacht J. Henley CM 3rd, et al. Among authors: schacht j. Biochem Pharmacol. 1988 May 1;37(9):1679-82. doi: 10.1016/0006-2952(88)90427-3. Biochem Pharmacol. 1988. PMID: 3377830
Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells.
Dulon D, Zajic G, Aran JM, Schacht J. Dulon D, et al. Among authors: schacht j. J Neurosci Res. 1989 Oct;24(2):338-46. doi: 10.1002/jnr.490240226. J Neurosci Res. 1989. PMID: 2585554
The mitochondrion: a perpetrator of acquired hearing loss.
Böttger EC, Schacht J. Böttger EC, et al. Among authors: schacht j. Hear Res. 2013 Sep;303:12-9. doi: 10.1016/j.heares.2013.01.006. Epub 2013 Jan 27. Hear Res. 2013. PMID: 23361190 Free PMC article. Review.
Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line.
Chen FQ, Hill K, Guan YJ, Schacht J, Sha SH. Chen FQ, et al. Among authors: schacht j. Hear Res. 2012 Feb;284(1-2):33-41. doi: 10.1016/j.heares.2011.12.007. Epub 2011 Dec 31. Hear Res. 2012. PMID: 22240458 Free PMC article.
Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics.
Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D. Sonousi A, et al. Among authors: schacht j. ACS Infect Dis. 2018 Jul 13;4(7):1114-1120. doi: 10.1021/acsinfecdis.8b00052. Epub 2018 May 10. ACS Infect Dis. 2018. PMID: 29708331 Free PMC article.
Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.
Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC. Duscha S, et al. Among authors: schacht j. mBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14. mBio. 2014. PMID: 25271289 Free PMC article.
Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo.
Oishi N, Kendall A, Schacht J. Oishi N, et al. Among authors: schacht j. Neurosci Lett. 2014 Nov 7;583:65-9. doi: 10.1016/j.neulet.2014.09.028. Epub 2014 Sep 18. Neurosci Lett. 2014. PMID: 25240593 Free PMC article.
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