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Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
Strowski MZ, Parmar RM, Blake AD, Schaeffer JM. Strowski MZ, et al. Endocrinology. 2000 Jan;141(1):111-7. doi: 10.1210/endo.141.1.7263. Endocrinology. 2000. PMID: 10614629
Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist.
Strowski MZ, Cashen DE, Birzin ET, Yang L, Singh V, Jacks TM, Nowak KW, Rohrer SP, Patchett AA, Smith RG, Schaeffer JM. Strowski MZ, et al. Among authors: schaeffer jm. Endocrinology. 2006 Oct;147(10):4664-73. doi: 10.1210/en.2006-0274. Epub 2006 Jul 20. Endocrinology. 2006. PMID: 16857751
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM. Rohrer SP, et al. Science. 1998 Oct 23;282(5389):737-40. doi: 10.1126/science.282.5389.737. Science. 1998. PMID: 9784130
High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice.
Martinez V, Curi AP, Torkian B, Schaeffer JM, Wilkinson HA, Walsh JH, Taché Y. Martinez V, et al. Gastroenterology. 1998 Jun;114(6):1125-32. doi: 10.1016/s0016-5085(98)70417-2. Gastroenterology. 1998. PMID: 9609748
Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.
Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA. Yang L, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41. doi: 10.1073/pnas.95.18.10836. Proc Natl Acad Sci U S A. 1998. PMID: 9724791 Free PMC article.
Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice.
Kaczmarek P, Singh V, Cashen DE, Yang L, Berk S, Pasternak A, Xiong Y, Shen DM, Hutchins SM, Chapman K, Wiedenmann B, Schaeffer JM, Strowski MZ. Kaczmarek P, et al. Among authors: schaeffer jm. Neurogastroenterol Motil. 2010 Feb;22(2):204-9, e66. doi: 10.1111/j.1365-2982.2009.01407.x. Epub 2009 Sep 15. Neurogastroenterol Motil. 2010. PMID: 19754922
Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.
Chen HY, Kim S, Wu JY, Birzin ET, Chan W, Yang YT, Dahllund J, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML. Chen HY, et al. Bioorg Med Chem Lett. 2004 May 17;14(10):2551-4. doi: 10.1016/j.bmcl.2004.02.084. Bioorg Med Chem Lett. 2004. PMID: 15109649
A beta-lactamase-dependent Gal4-estrogen receptor beta transactivation assay for the ultra-high throughput screening of estrogen receptor beta agonists in a 3456-well format.
Peekhaus NT, Ferrer M, Chang T, Kornienko O, Schneeweis JE, Smith TS, Hoffman I, Mitnaul LJ, Chin J, Fischer PA, Blizzard TA, Birzin ET, Chan W, Inglese J, Strulovici B, Rohrer SP, Schaeffer JM. Peekhaus NT, et al. Assay Drug Dev Technol. 2003 Dec;1(6):789-800. doi: 10.1089/154065803772613426. Assay Drug Dev Technol. 2003. PMID: 15090225
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.
Kim S, Wu JY, Birzin ET, Frisch K, Chan W, Pai LY, Yang YT, Mosley RT, Fitzgerald PM, Sharma N, Dahllund J, Thorsell AG, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML. Kim S, et al. J Med Chem. 2004 Apr 22;47(9):2171-5. doi: 10.1021/jm034243o. J Med Chem. 2004. PMID: 15084115
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