Schaffer AE - Search Results

1

Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.

Schaffer AE, Freude KK, Nelson SB, Sander M. Schaffer AE, et al. Dev Cell. 2010 Jun 15;18(6):1022-9. doi: 10.1016/j.devcel.2010.05.015. Dev Cell. 2010. PMID: 20627083 Free PMC article.

2

The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.

Nelson SB, Schaffer AE, Sander M. Nelson SB, et al. Among authors: schaffer ae. Development. 2007 Jul;134(13):2491-500. doi: 10.1242/dev.002691. Epub 2007 May 30. Development. 2007. PMID: 17537793

3

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.

Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M. Kopp JL, et al. Among authors: schaffer ae. Development. 2011 Feb;138(4):653-65. doi: 10.1242/dev.056499. Development. 2011. PMID: 21266405 Free PMC article.

4

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M. Schaffer AE, et al. Mol Endocrinol. 2011 Nov;25(11):1904-14. doi: 10.1210/me.2011-1010. Epub 2011 Sep 29. Mol Endocrinol. 2011. PMID: 21964593 Free PMC article.

5

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.

Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. Schaffer AE, et al. PLoS Genet. 2013;9(1):e1003274. doi: 10.1371/journal.pgen.1003274. Epub 2013 Jan 31. PLoS Genet. 2013. PMID: 23382704 Free PMC article.

6

TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome.

Werren EA, LaForce GR, Srivastava A, Perillo DR, Li S, Johnson K, Baris S, Berger B, Regan SL, Pfennig CD, de Munnik S, Pfundt R, Hebbar M, Jimenez-Heredia R, Karakoc-Aydiner E, Ozen A, Dmytrus J, Krolo A, Corning K, Prijoles EJ, Louie RJ, Lebel RR, Le TL, Amiel J, Gordon CT, Boztug K, Girisha KM, Shukla A, Bielas SL, Schaffer AE. Werren EA, et al. Among authors: schaffer ae. Nat Commun. 2024 Feb 22;15(1):1640. doi: 10.1038/s41467-024-45948-y. Nat Commun. 2024. PMID: 38388531 Free PMC article.

7

Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS.

Chen D, Philippidou P, Brenha BF, Schaffer AE, Miranda HC. Chen D, et al. Among authors: schaffer ae. bioRxiv [Preprint]. 2024 Jan 12:2024.01.11.575304. doi: 10.1101/2024.01.11.575304. bioRxiv. 2024. PMID: 38260655 Free PMC article. Preprint.

8

Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants.

Zhang PP, Benske TM, Ahn LY, Schaffer AE, Paton JC, Paton AW, Mu TW, Wang YJ. Zhang PP, et al. Among authors: schaffer ae. Acta Pharmacol Sin. 2024 Feb;45(2):282-297. doi: 10.1038/s41401-023-01172-w. Epub 2023 Oct 6. Acta Pharmacol Sin. 2024. PMID: 37803141

9

Pharmacological chaperones restore proteostasis of epilepsy-associated GABA_A receptor variants.

Wang YJ, Seibert H, Ahn LY, Schaffer AE, Mu TW. Wang YJ, et al. Among authors: schaffer ae. bioRxiv [Preprint]. 2023 Apr 19:2023.04.18.537383. doi: 10.1101/2023.04.18.537383. bioRxiv. 2023. PMID: 37131660 Free PMC article. Preprint.

10

mRNA isoform balance in neuronal development and disease.

LaForce GR, Philippidou P, Schaffer AE. LaForce GR, et al. Among authors: schaffer ae. Wiley Interdiscip Rev RNA. 2023 May-Jun;14(3):e1762. doi: 10.1002/wrna.1762. Epub 2022 Sep 19. Wiley Interdiscip Rev RNA. 2023. PMID: 36123820 Review.

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