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Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.
Sell GL, Schaffer TB, Margolis SS. Sell GL, et al. Among authors: schaffer tb. J Clin Invest. 2017 May 1;127(5):1646-1650. doi: 10.1172/JCI85504. Epub 2017 Mar 27. J Clin Invest. 2017. PMID: 28346227 Free PMC article.
PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
Schaffer TB, Smith JE, Cook EK, Phan T, Margolis SS. Schaffer TB, et al. Cell Rep. 2018 Nov 27;25(9):2470-2483.e8. doi: 10.1016/j.celrep.2018.11.005. Cell Rep. 2018. PMID: 30485813 Free PMC article.
ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase.
Schmidt K, Ralle M, Schaffer T, Jayakanthan S, Bari B, Muchenditsi A, Lutsenko S. Schmidt K, et al. J Biol Chem. 2018 Dec 28;293(52):20085-20098. doi: 10.1074/jbc.RA118.004889. Epub 2018 Oct 19. J Biol Chem. 2018. PMID: 30341172 Free PMC article.
Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome.
Ramachandran KV, Fu JM, Schaffer TB, Na CH, Delannoy M, Margolis SS. Ramachandran KV, et al. Among authors: schaffer tb. Mol Cell. 2018 Jul 5;71(1):169-177.e6. doi: 10.1016/j.molcel.2018.06.013. Mol Cell. 2018. PMID: 29979964 Free PMC article.
A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival.
Chan W, Schaffer TB, Pomerantz JL. Chan W, et al. Among authors: schaffer tb. Mol Cell Biol. 2013 Jan;33(2):429-43. doi: 10.1128/MCB.00850-12. Epub 2012 Nov 12. Mol Cell Biol. 2013. PMID: 23149938 Free PMC article.
The emergence of Ephexin5 as a therapeutic target in Alzheimer's disease.
Cook EK, Sell GL, Schaffer TB, Margolis SS. Cook EK, et al. Among authors: schaffer tb. Expert Opin Ther Targets. 2019 Apr;23(4):263-265. doi: 10.1080/14728222.2019.1586884. Epub 2019 Mar 5. Expert Opin Ther Targets. 2019. PMID: 30810053 Free PMC article. No abstract available.
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