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Decreased phenylalanine uptake and turnover in patients with vitiligo.
Schallreuter KU, Chavan B, Rokos H, Hibberts N, Panske A, Wood JM. Schallreuter KU, et al. Mol Genet Metab. 2005 Dec;86 Suppl 1:S27-33. doi: 10.1016/j.ymgme.2005.07.023. Epub 2005 Sep 6. Mol Genet Metab. 2005. PMID: 16143555 Review.
The redox--biochemistry of human hair pigmentation.
Schallreuter KU, Salem MM, Hasse S, Rokos H. Schallreuter KU, et al. Pigment Cell Melanoma Res. 2011 Feb;24(1):51-62. doi: 10.1111/j.1755-148X.2010.00794.x. Epub 2010 Dec 1. Pigment Cell Melanoma Res. 2011. PMID: 20958953
Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels.
Schallreuter KU, Salem MA, Gibbons NC, Martinez A, Slominski R, Lüdemann J, Rokos H. Schallreuter KU, et al. FASEB J. 2012 Jun;26(6):2457-70. doi: 10.1096/fj.11-197137. Epub 2012 Mar 13. FASEB J. 2012. PMID: 22415302
Basic evidence for epidermal H2O2/ONOO(-)-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS.
Schallreuter KU, Salem MA, Holtz S, Panske A. Schallreuter KU, et al. FASEB J. 2013 Aug;27(8):3113-22. doi: 10.1096/fj.12-226779. Epub 2013 Apr 29. FASEB J. 2013. PMID: 23629861
Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 2: Epidermal H2O2/ONOO(-)-mediated stress in vitiligo hampers indoleamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immune response signaling.
Schallreuter KU, Salem MA, Gibbons NC, Maitland DJ, Marsch E, Elwary SM, Healey AR. Schallreuter KU, et al. FASEB J. 2012 Jun;26(6):2471-85. doi: 10.1096/fj.11-201897. Epub 2012 Mar 13. FASEB J. 2012. PMID: 22415306
Basic research confirms coexistence of acquired Blaschkolinear Vitiligo and acrofacial Vitiligo.
Schallreuter KU, Krüger C, Rokos H, Hasse S, Zothner C, Panske A. Schallreuter KU, et al. Arch Dermatol Res. 2007 Aug;299(5-6):225-30. doi: 10.1007/s00403-007-0748-7. Epub 2007 Apr 3. Arch Dermatol Res. 2007. PMID: 17404749
Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates.
Schallreuter KU, Gibbons NC, Elwary SM, Parkin SM, Wood JM. Schallreuter KU, et al. Biochem Biophys Res Commun. 2007 Apr 20;355(4):1069-74. doi: 10.1016/j.bbrc.2007.02.078. Epub 2007 Feb 23. Biochem Biophys Res Commun. 2007. PMID: 17335779
Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress.
Hasse S, Gibbons NC, Rokos H, Marles LK, Schallreuter KU. Hasse S, et al. Among authors: schallreuter ku. J Invest Dermatol. 2004 Feb;122(2):307-13. doi: 10.1046/j.0022-202X.2004.22230.x. J Invest Dermatol. 2004. PMID: 15009710
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo.
Schallreuter KU, Elwary SM, Gibbons NC, Rokos H, Wood JM. Schallreuter KU, et al. Biochem Biophys Res Commun. 2004 Mar 5;315(2):502-8. doi: 10.1016/j.bbrc.2004.01.082. Biochem Biophys Res Commun. 2004. PMID: 14766237
In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes.
Schallreuter KU, Kothari S, Hasse S, Kauser S, Lindsey NJ, Gibbons NC, Hibberts N, Wood JM. Schallreuter KU, et al. Biochem Biophys Res Commun. 2003 Feb 7;301(2):610-6. doi: 10.1016/s0006-291x(02)03076-0. Biochem Biophys Res Commun. 2003. PMID: 12565907
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