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Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.
Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J. Worthmann A, et al. Among authors: schaltenberg n. Nat Med. 2017 Jul;23(7):839-849. doi: 10.1038/nm.4357. Epub 2017 Jun 12. Nat Med. 2017. PMID: 28604703
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.
Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J. Bartelt A, et al. Among authors: schaltenberg n. Nat Commun. 2017 Apr 19;8:15010. doi: 10.1038/ncomms15010. Nat Commun. 2017. PMID: 28422089 Free PMC article. Clinical Trial.
Short-term dietary changes can result in mucosal and systemic immune depression.
Siracusa F, Schaltenberg N, Kumar Y, Lesker TR, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks BP, Bönisch F, Fischer AW, Scognamiglio P, Pauly MJ, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker HW, Kretz O, Guse AH, Izbicki JR, Lassen KG, Strowig T, Schweizer M, Villablanca EJ, Elinav E, Huber S, Heeren J, Gagliani N. Siracusa F, et al. Among authors: schaltenberg n. Nat Immunol. 2023 Sep;24(9):1473-1486. doi: 10.1038/s41590-023-01587-x. Epub 2023 Aug 14. Nat Immunol. 2023. PMID: 37580603 Free PMC article.
Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.
Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The SML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. Schreurs RRCE, et al. Among authors: schaltenberg n. Immunity. 2019 Feb 19;50(2):462-476.e8. doi: 10.1016/j.immuni.2018.12.010. Epub 2019 Feb 12. Immunity. 2019. PMID: 30770246 Free article.
Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.
Wuensch T, Ullrich S, Schulz S, Chamaillard M, Schaltenberg N, Rath E, Goebel U, Sartor RB, Prager M, Büning C, Bugert P, Witt H, Haller D, Daniel H. Wuensch T, et al. Among authors: schaltenberg n. Inflamm Bowel Dis. 2014 Apr;20(4):671-84. doi: 10.1097/01.MIB.0000443336.71488.08. Inflamm Bowel Dis. 2014. PMID: 24583477
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