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MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. Constantinides MG, et al. Among authors: scharschmidt tc. Science. 2019 Oct 25;366(6464):eaax6624. doi: 10.1126/science.aax6624. Science. 2019. PMID: 31649166 Free PMC article.
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC. Leech JM, et al. Among authors: scharschmidt tc. Cell Host Microbe. 2019 Dec 11;26(6):795-809.e5. doi: 10.1016/j.chom.2019.10.007. Epub 2019 Nov 26. Cell Host Microbe. 2019. PMID: 31784259 Free PMC article.
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. Dhariwala MO, et al. Among authors: scharschmidt tc. Cell Rep Med. 2020 Nov 3;1(8):100132. doi: 10.1016/j.xcrm.2020.100132. eCollection 2020 Nov 17. Cell Rep Med. 2020. PMID: 33294857 Free PMC article.
Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. Merana GR, et al. Among authors: scharschmidt tc. Cell Rep. 2022 May 31;39(9):110891. doi: 10.1016/j.celrep.2022.110891. Cell Rep. 2022. PMID: 35649365 Free PMC article.
Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.
Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC. Weckel A, et al. Among authors: scharschmidt tc. Immunity. 2023 Jun 13;56(6):1239-1254.e7. doi: 10.1016/j.immuni.2023.03.008. Epub 2023 Apr 6. Immunity. 2023. PMID: 37028427
Skin Dysbiosis Goes "Off-Leish".
Scharschmidt TC. Scharschmidt TC. Cell Host Microbe. 2017 Jul 12;22(1):1-3. doi: 10.1016/j.chom.2017.06.017. Cell Host Microbe. 2017. PMID: 28704646 Free article.
45 results