Scheer N - Search Results

1

Xenobiotic receptor humanized mice and their utility.

Scheer N, Roland Wolf C. Scheer N, et al. Drug Metab Rev. 2013 Feb;45(1):110-21. doi: 10.3109/03602532.2012.738687. Epub 2012 Nov 23. Drug Metab Rev. 2013. PMID: 23173549 Review.

2

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M. Kazuki Y, et al. Among authors: scheer n. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4. Proc Natl Acad Sci U S A. 2019. PMID: 30718425 Free PMC article.

3

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.

Dallas S, Salphati L, Gomez-Zepeda D, Wanek T, Chen L, Chu X, Kunta J, Mezler M, Menet MC, Chasseigneaux S, Declèves X, Langer O, Pierre E, DiLoreto K, Hoft C, Laplanche L, Pang J, Pereira T, Andonian C, Simic D, Rode A, Yabut J, Zhang X, Scheer N. Dallas S, et al. Among authors: scheer n. Mol Pharmacol. 2016 May;89(5):492-504. doi: 10.1124/mol.115.102079. Epub 2016 Feb 18. Mol Pharmacol. 2016. PMID: 26893303

4

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.

Kapelyukh Y, Henderson CJ, Scheer N, Rode A, Wolf CR. Kapelyukh Y, et al. Among authors: scheer n. Drug Metab Dispos. 2019 Aug;47(8):907-918. doi: 10.1124/dmd.119.087718. Epub 2019 May 30. Drug Metab Dispos. 2019. PMID: 31147315 Free PMC article.

5

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.

Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG. Luisier R, et al. Among authors: scheer n. Toxicol Sci. 2014 Jun;139(2):501-11. doi: 10.1093/toxsci/kfu038. Epub 2014 Apr 1. Toxicol Sci. 2014. PMID: 24690595

6

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.

Stanley LA, Horsburgh BC, Ross J, Scheer N, Wolf CR. Stanley LA, et al. Among authors: scheer n. Drug Metab Rev. 2006;38(3):515-97. doi: 10.1080/03602530600786232. Drug Metab Rev. 2006. PMID: 16877263 Review.

7

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR. Scheer N, et al. J Clin Invest. 2008 Sep;118(9):3228-39. doi: 10.1172/JCI35483. J Clin Invest. 2008. PMID: 18677425 Free PMC article.

8

Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms.

Hough LB, Nalwalk JW, Ding X, Scheer N. Hough LB, et al. Among authors: scheer n. Drug Metab Dispos. 2015 Sep;43(9):1326-30. doi: 10.1124/dmd.115.065490. Epub 2015 Jun 24. Drug Metab Dispos. 2015. PMID: 26109562 Free PMC article.

9

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism.

Scheer N, McLaughlin LA, Rode A, Macleod AK, Henderson CJ, Wolf CR. Scheer N, et al. Drug Metab Dispos. 2014 Jun;42(6):1022-30. doi: 10.1124/dmd.114.057885. Epub 2014 Mar 26. Drug Metab Dispos. 2014. PMID: 24671958

10

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.

Scheer N, Kapelyukh Y, Chatham L, Rode A, Buechel S, Wolf CR. Scheer N, et al. Mol Pharmacol. 2012 Dec;82(6):1022-9. doi: 10.1124/mol.112.080036. Epub 2012 Aug 23. Mol Pharmacol. 2012. PMID: 22918969

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