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c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity.
Chan AL, Grossman T, Zuckerman V, Campigli Di Giammartino D, Moshel O, Scheffner M, Monahan B, Pilling P, Jiang YH, Haupt S, Schueler-Furman O, Haupt Y. Chan AL, et al. Biochemistry. 2013 May 7;52(18):3119-29. doi: 10.1021/bi301710c. Epub 2013 Apr 26. Biochemistry. 2013. PMID: 23581475
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.
Hengstermann A, D'silva MA, Kuballa P, Butz K, Hoppe-Seyler F, Scheffner M. Hengstermann A, et al. J Virol. 2005 Jul;79(14):9296-300. doi: 10.1128/JVI.79.14.9296-9300.2005. J Virol. 2005. PMID: 15994823 Free PMC article.
Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells.
Honegger A, Schilling D, Bastian S, Sponagel J, Kuryshev V, Sültmann H, Scheffner M, Hoppe-Seyler K, Hoppe-Seyler F. Honegger A, et al. PLoS Pathog. 2015 Mar 11;11(3):e1004712. doi: 10.1371/journal.ppat.1004712. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25760330 Free PMC article.
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.
Heideman DA, Steenbergen RD, van der Torre J, Scheffner M, Alemany R, Gerritsen WR, Meijer CJ, Snijders PJ, van Beusechem VW. Heideman DA, et al. Mol Ther. 2005 Dec;12(6):1083-90. doi: 10.1016/j.ymthe.2005.06.443. Epub 2005 Aug 8. Mol Ther. 2005. PMID: 16085463
A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein.
Dymalla S, Scheffner M, Weber E, Sehr P, Lohrey C, Hoppe-Seyler F, Hoppe-Seyler K. Dymalla S, et al. J Mol Med (Berl). 2009 Mar;87(3):321-31. doi: 10.1007/s00109-008-0432-1. Epub 2008 Dec 21. J Mol Med (Berl). 2009. PMID: 19099279
Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53.
Xirodimas DP, Scheffner M. Xirodimas DP, et al. Subcell Biochem. 2010;54:116-35. doi: 10.1007/978-1-4419-6676-6_10. Subcell Biochem. 2010. PMID: 21222278
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