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PKB/AKT: functional insights from genetic models.
Scheid MP, Woodgett JR. Scheid MP, et al. Nat Rev Mol Cell Biol. 2001 Oct;2(10):760-8. doi: 10.1038/35096067. Nat Rev Mol Cell Biol. 2001. PMID: 11584303 Review.
Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice.
Scheid MP, Huber M, Damen JE, Hughes M, Kang V, Neilsen P, Prestwich GD, Krystal G, Duronio V. Scheid MP, et al. J Biol Chem. 2002 Mar 15;277(11):9027-35. doi: 10.1074/jbc.M106755200. Epub 2002 Jan 7. J Biol Chem. 2002. PMID: 11781306
Serine 396 of PDK1 is required for maximal PKB activation.
Moon Z, Wang Y, Aryan N, Mousseau DD, Scheid MP. Moon Z, et al. Among authors: scheid mp. Cell Signal. 2008 Nov;20(11):2038-49. doi: 10.1016/j.cellsig.2008.07.015. Epub 2008 Jul 30. Cell Signal. 2008. PMID: 18718528
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